Seroatlas · Human Serome Atlas

MAGEA12

Melanoma-associated antigen 12

Also known as: CT1.12, MAGAC_HUMAN, MAGE12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P43365
Gene: MAGEA12
Ensembl: ENSG00000213401
Chromosome: X
Canonical length: 314 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>P43365|MAGEA12
     1  MPLEQRSQHC KPEEGLEAQG EALGLVGAQA PATEEQETAS SSSTLVEVTL REVPAAESPS
    61  PPHSPQGAST LPTTINYTLW SQSDEGSSNE EQEGPSTFPD LETSFQVALS RKMAELVHFL
   121  LLKYRAREPF TKAEMLGSVI RNFQDFFPVI FSKASEYLQL VFGIEVVEVV RIGHLYILVT
   181  CLGLSYDGLL GDNQIVPKTG LLIIVLAIIA KEGDCAPEEK IWEELSVLEA SDGREDSVFA
   241  HPRKLLTQDL VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHL LKISGGPHIS
   301  YPPLHEWAFR EGEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEA12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

testis: 2.7 nTPM
basal ganglia: 0.4 nTPM
amygdala: 0.3 nTPM
cerebral cortex: 0.3 nTPM
hippocampal formation: 0.3 nTPM
midbrain: 0.3 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
amygdala: 0.2 nTPM
midbrain: 0.2 nTPM
pons: 0.2 nTPM
thalamus: 0.2 nTPM
white matter: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAGEA12.

Disease | ImmuneIEDB

Conditions an epitope on MAGEA12 was assayed in.

melanoma T cell
skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.41
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Tumor antigen

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEA12 as an antibody target. Whether an autoantibody or antibody against MAGEA12 could matter depends on whether native MAGEA12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEA12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEA12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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