Seroatlas · Human Serome Atlas

MAGEB10

Melanoma-associated antigen B10

Also known as: FLJ32965, MAGBA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LZ2
Gene: MAGEB10
Ensembl: ENSG00000177689
Chromosome: X
Canonical length: 347 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q96LZ2|MAGEB10
     1  MPRGQKSKLR AREKRRQARG GLEDLIDALD ILEEEEESPP SASACLKDVF QSSLDGASNN
    61  PHGLREAQST STSATAASHT RHPEGVNDQM EERPICTQDL EATDSFPRGP VDEKVIILVH
   121  YLLYKYQMKE PITKADMLRN VTQMSKSQFP VILSRASEHL ELIFGLDLKE VEPNKHIYVL
   181  VNKLDLGCDA KLSDETGVPK TGLLMTVLGI IFTNGNCVAE EEVWKVFNTM GLYDGIEHFM
   241  FGEPRKLLTK DLVKENYLEY QQVPNSDPPR YQFLWGPRAH AETSKMKVLE FLAKVNDTAP
   301  SEFSNWYTEA LQDEEERARA RVAAKARVSA TAGARSKVKS SKSSQLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

testis: 2.3 nTPM
bone marrow: 0.3 nTPM
skin: 0.2 nTPM
lymph node: 0.1 nTPM
retina: 0.1 nTPM
salivary gland: 0.1 nTPM

Single-cell type

differentiating spermatogonia: 13 nCPM
early primary spermatocytes: 11 nCPM
undifferentiated spermatogonia: 2.7 nCPM
schwann cells: 0.4 nCPM
sertoli cells: 0.3 nCPM
early spermatids: 0.2 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

white matter: 2.4 nTPM
cerebellum: 2 nTPM
cerebral cortex: 2 nTPM
choroid plexus: 2 nTPM
hippocampal formation: 1.9 nTPM
medulla oblongata: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 1.37
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Tumor antigen

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEB10 as an antibody target. Whether an autoantibody or antibody against MAGEB10 could matter depends on whether native MAGEB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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