MAGEB1

Protein identityUniProt · HPA

UniProt accession

P43366

Gene

MAGEB1

Ensembl

ENSG00000214107

Chromosome

X

Canonical length

347 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>P43366|MAGEB1
     1  MPRGQKSKLR AREKRRKARE ETQGLKVAHA TAAEKEECPS SSPVLGDTPT SSPAAGIPQK
    61  PQGAPPTTTA AAAVSCTESD EGAKCQGEEN ASFSQATTST ESSVKDPVAW EAGMLMHFIL
   121  RKYKMREPIM KADMLKVVDE KYKDHFTEIL NGASRRLELV FGLDLKEDNP SGHTYTLVSK
   181  LNLTNDGNLS NDWDFPRNGL LMPLLGVIFL KGNSATEEEI WKFMNVLGAY DGEEHLIYGE
   241  PRKFITQDLV QEKYLKYEQV PNSDPPRYQF LWGPRAYAET TKMKVLEFLA KMNGATPRDF
   301  PSHYEEALRD EEERAQVRSS VRARRRTTAT TFRARSRAPF SRSSHPM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

14 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z

0.14

DepMap mean gene effect

0.15

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of transcription by RNA polymerase II

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• MAGE homology domain
• Melanoma associated antigen, N-terminal
• Melanoma-associated antigen
• MAGE homology domain, winged helix WH1 motif
• MAGE homology domain, winged helix WH2 motif
• MAGE homology domain
• Melanoma associated antigen family N terminal

KeywordsUniProt

• Tumor antigen