Seroatlas · Human Serome Atlas

ADPRM

Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

Also known as: ADPRM_HUMAN, C17orf48, MDS006

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3LIE5
Gene
ADPRM
Ensembl
ENSG00000170222
Chromosome
17
Canonical length
342 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; manganese ion binding activity; and pyrophosphatase activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q3LIE5|ADPRM
     1  MDDKPNPEAL SDSSERLFSF GVIADVQFAD LEDGFNFQGT RRRYYRHSLL HLQGAIEDWN
    61  NESSMPCCVL QLGDIIDGYN AQYNASKKSL ELVMDMFKRL KVPVHHTWGN HEFYNFSREY
   121  LTHSKLNTKF LEDQIVHHPE TMPSEDYYAY HFVPFPKFRF ILLDAYDLSV LGVDQSSPKY
   181  EQCMKILREH NPNTELNSPQ GLSEPQFVQF NGGFSQEQLN WLNEVLTFSD TNQEKVVIVS
   241  HLPIYPDASD NVCLAWNYRD ALAVIWSHEC VVCFFAGHTH DGGYSEDPFG VYHVNLEGVI
   301  ETAPDSQAFG TVHVYPDKMM LKGRGRVPDR IMNYKKERAF HC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADPRM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
9.2 nTPM

Expression across tissuesHPA

Tissue

  • retina: 9.2 nTPM
  • prostate: 7.2 nTPM
  • skeletal muscle: 6.8 nTPM
  • ovary: 6.5 nTPM
  • thymus: 6.5 nTPM
  • liver: 6.4 nTPM

Single-cell type

  • rod photoreceptor cells: 56 nCPM
  • hematopoietic stem cells: 41 nCPM
  • myonuclei: 28 nCPM
  • b-cells: 28 nCPM
  • megakaryocyte-erythroid progenitors: 27 nCPM
  • thymic myoid cells: 25 nCPM

Immune cell

  • naive CD4 T-cell: 13 nTPM
  • naive CD8 T-cell: 8.6 nTPM
  • naive B-cell: 7.2 nTPM
  • memory CD4 T-cell: 6.2 nTPM
  • memory B-cell: 5.9 nTPM
  • T-reg: 5.9 nTPM

Brain region

  • white matter: 5.2 nTPM
  • cerebral cortex: 5.1 nTPM
  • thalamus: 5.1 nTPM
  • basal ganglia: 4.8 nTPM
  • hypothalamus: 4.8 nTPM
  • cerebellum: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
1.01
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADPRM as an antibody target. Whether an autoantibody or antibody against ADPRM could matter depends on whether native ADPRM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADPRM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADPRM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADPRM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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