Seroatlas · Human Serome Atlas

SMPDL3A

Cyclic GMP-AMP phosphodiesterase SMPDL3A

Also known as: ASM3A, ASM3A_HUMAN, ASML3a, FLJ20177, yR36GH4.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92484
Gene: SMPDL3A
Ensembl: ENSG00000172594
Chromosome: 6
Canonical length: 453 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitochondria
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables phosphoric diester hydrolase activity and zinc ion binding activity. Involved in negative regulation of cGAS/STING signaling pathway and nucleoside triphosphate catabolic process. Located in extracellular exosome. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q92484|SMPDL3A
     1  MALVRALVCC LLTAWHCRSG LGLPVAPAGG RNPPPAIGQF WHVTDLHLDP TYHITDDHTK
    61  VCASSKGANA SNPGPFGDVL CDSPYQLILS AFDFIKNSGQ EASFMIWTGD SPPHVPVPEL
   121  STDTVINVIT NMTTTIQSLF PNLQVFPALG NHDYWPQDQL PVVTSKVYNA VANLWKPWLD
   181  EEAISTLRKG GFYSQKVTTN PNLRIISLNT NLYYGPNIMT LNKTDPANQF EWLESTLNNS
   241  QQNKEKVYII AHVPVGYLPS SQNITAMREY YNEKLIDIFQ KYSDVIAGQF YGHTHRDSIM
   301  VLSDKKGSPV NSLFVAPAVT PVKSVLEKQT NNPGIRLFQY DPRDYKLLDM LQYYLNLTEA
   361  NLKGESIWKL EYILTQTYDI EDLQPESLYG LAKQFTILDS KQFIKYYNYF FVSYDSSVTC
   421  DKTCKAFQIC AIMNLDNISY ADCLKQLYIK HNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMPDL3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

liver: 75 nTPM
small intestine: 73 nTPM
rectum: 62 nTPM
skin: 61 nTPM
colon: 57 nTPM
tongue: 52 nTPM

Single-cell type

enterocytes: 379 nCPM
kupffer cells: 293 nCPM
colonocytes: 179 nCPM
cytotrophoblasts: 168 nCPM
migrating cytotrophoblasts: 166 nCPM
foveolar cells: 150 nCPM

Immune cell

basophil: 81 nTPM
non-classical monocyte: 7.5 nTPM
intermediate monocyte: 4.3 nTPM
classical monocyte: 4 nTPM
total PBMC: 1.4 nTPM
neutrophil: 1.3 nTPM

Brain region

choroid plexus: 16 nTPM
cerebellum: 14 nTPM
white matter: 13 nTPM
pons: 9.5 nTPM
medulla oblongata: 9.4 nTPM
spinal cord: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMPDL3A as an antibody target. Whether an autoantibody or antibody against SMPDL3A could matter depends on whether native SMPDL3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMPDL3A is annotated as secreted, so native SMPDL3A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SMPDL3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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