Seroatlas · Human Serome Atlas

MRE11

Double-strand break repair protein MRE11

Also known as: ATLD, MRE11_HUMAN, MRE11A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49959
Gene: MRE11
Ensembl: ENSG00000020922
Chromosome: 11
Canonical length: 708 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

708 residues, UniProt reviewed canonical sequence.

>P49959|MRE11
     1  MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN EVDFILLGGD
    61  LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN FGFSKFPWVN YQDGNLNISI
   121  PVFSIHGNHD DPTGADALCA LDILSCAGFV NHFGRSMSVE KIDISPVLLQ KGSTKIALYG
   181  LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL
   241  VIWGHEHECK IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP
   301  LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE RLGNSHQPEK
   361  PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR HREQKEKTGE EINFGKLITK
   421  PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK
   481  TQRFLKERHI DALEDKIDEE VRRFRETRQK NTNEEDDEVR EAMTRARALR SQSEESASAF
   541  SADDLMSIDL AEQMANDSDD SISAATNKGR GRGRGRRGGR GQNSASRGGS QRGRADTGLE
   601  TSTRSRNSKT AVSASRNMSI IDAFKSTRQQ PSRNVTTKNY SEVIEVDESD VEEDIFPTTS
   661  KTDQRWSSTS SSKIMSQSQV SKGVDFESSE DDDDDPFMNT SSLRRNRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRE11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 21 nTPM
tonsil: 15 nTPM
skin: 15 nTPM
thymus: 13 nTPM
breast: 13 nTPM
spleen: 12 nTPM

Single-cell type

ependymal cells: 112 nCPM
erythrocyte progenitors: 104 nCPM
neutrophil progenitors: 97 nCPM
thymocytes: 95 nCPM
monocyte progenitors: 84 nCPM
megakaryocyte progenitors: 79 nCPM

Immune cell

myeloid DC: 12 nTPM
intermediate monocyte: 10 nTPM
memory CD8 T-cell: 8.9 nTPM
T-reg: 8.9 nTPM
NK-cell: 8.7 nTPM
plasmacytoid DC: 8.7 nTPM

Brain region

cerebellum: 24 nTPM
white matter: 23 nTPM
choroid plexus: 23 nTPM
medulla oblongata: 21 nTPM
midbrain: 19 nTPM
spinal cord: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRE11.

Disease | AllUniProt

Conditions MRE11 is implicated in, by any mechanism.

Ataxia-telangiectasia-like disorder 1 (ATLD1) MIM:604391

Disease | GeneticClinVar

190 pathogenic / likely-pathogenic of 2,445 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hereditary cancer-predisposing syndrome
Ataxia-telangiectasia-like disorder
Ataxia-telangiectasia-like disorder 1
Hereditary breast ovarian cancer syndrome
Breast carcinoma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Calcineurin-like, phosphoesterase domain
Metallo-dependent phosphatase-like
Calcineurin-like phosphoesterase
DNA double-strand break repair protein Mre11
Mre11, DNA-binding
Mre11, capping domain
DNA double-strand break repair protein Mre11, N-terminal metallophosphatase domain
Mre11 DNA-binding presumed domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRE11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRE11 as an antibody target. Whether an autoantibody or antibody against MRE11 could matter depends on whether native MRE11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRE11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRE11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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