Seroatlas · Human Serome Atlas

TMEM62

Transmembrane protein 62

Also known as: FLJ23375, TMM62_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0P6H9
Gene: TMEM62
Ensembl: ENSG00000137842
Chromosome: 15
Canonical length: 643 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Nuclear bodies,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to enable hydrolase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>Q0P6H9|TMEM62
     1  MAAVLALRVV AGLAAAALVA MLLEHYGLAG QPSPLPRPAP PRRPHPAPGP GDSNIFWGLQ
    61  ISDIHLSRFR DPGRAVDLEK FCSETIDIIQ PALVLATGDL TDAKTKEQLG SRQHEVEWQT
   121  YQGILKKTRV MEKTKWLDIK GNHDAFNIPS LDSIKNYYRK YSAVRRDGSF HYVHSTPFGN
   181  YSFICVDATV NPGPKRPYNF FGILDKKKME ELLLLAKESS RSNHTIWFGH FTTSTILSPS
   241  PGIRSIMSSA IAYLCGHLHT LGGLMPVLHT RHFQGTLELE VGDWKDNRRY RIFAFDHDLF
   301  SFADLIFGKW PVVLITNPKS LLYSCGEHEP LERLLHSTHI RVLAFSLSSI TSVTVKIDGV
   361  HLGQAVHVSG PIFVLKWNPR NYSSGTHNIE VIVQDSAGRS KSVHHIFSVQ ENNHLSFDPL
   421  ASFILRTDHY IMARVLFVLI VLSQLTILII FRYRGYPELK EPSGFINLTS FSLHVLSKIN
   481  IFYYSVLLLT LYTVLGPWFF GEIIDGKFGC CFSFGIFVNG HFLQGSITFI IGILQLAFFN
   541  IPLMAYMCWS LLQRCFGHNF RSHLHQRKYL KIMPVHLLML LLYIWQVYSC YFLYATYGTL
   601  AFLFSPLRTW LTLLTPVLIR YVWTLNSTKF GIFMVQLKSH LSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

breast: 22 nTPM
rectum: 14 nTPM
parathyroid gland: 13 nTPM
salivary gland: 13 nTPM
colon: 12 nTPM
duodenum: 12 nTPM

Single-cell type

syncytiotrophoblasts: 71 nCPM
b-cells: 68 nCPM
neutrophil progenitors: 63 nCPM
retinal ganglion cells: 62 nCPM
respiratory secretory cells: 59 nCPM
thymocytes: 58 nCPM

Immune cell

T-reg: 2 nTPM
plasmacytoid DC: 1.7 nTPM
NK-cell: 1.6 nTPM
eosinophil: 1.1 nTPM
memory CD4 T-cell: 1.1 nTPM
MAIT T-cell: 1 nTPM

Brain region

cerebellum: 19 nTPM
white matter: 14 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 13 nTPM
pons: 13 nTPM
spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

hydrolase activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Calcineurin-like, phosphoesterase domain
Metallo-dependent phosphatase-like
Calcineurin-like phosphoesterase
TMEM62, metallophosphatase domain
TMEM62, Ig-like domain
TMEM62, C-terminal domain
TMEM62 Ig-like domain
TMEM62 C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM62 as an antibody target. Whether an autoantibody or antibody against TMEM62 could matter depends on whether native TMEM62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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