Seroatlas · Human Serome Atlas

MPPED1

Metallophosphoesterase domain-containing protein 1

Also known as: 239AB, C22orf1, FAM1A, MPPD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15442
Gene: MPPED1
Ensembl: ENSG00000186732
Chromosome: 22
Canonical length: 326 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable hydrolase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>O15442|MPPED1
     1  MWRSRWDASV LKAEALALLP CGLGMAFSQS HVMAARRHQH SRLIIEVDEY SSNPTQAFTF
    61  YNINQGRFQP PHVQMVDPVP HDAPKPPGYT RFVCVSDTHS RTDPIQMPYG DVLIHAGDFT
   121  ELGLPSEVKK FNEWLGSLPY EYKIVIAGNH ELTFDQEFMA DLIKQDFYYF PSVSKLKPEN
   181  YENVQSLLTN CIYLQDSEVT VRGFRIYGSP WQPWFYGWGF NLPRGQALLE KWNLIPEGVD
   241  ILITHGPPLG FLDWVPKKMQ RVGCVELLNT VQRRVQPRLH VFGHIHEGYG VMADGTTTYV
   301  NASVCTVNYQ PVNPPIVIDL PTPRNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPPED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 52 nTPM
hippocampal formation: 27 nTPM
liver: 22 nTPM
amygdala: 15 nTPM
midbrain: 4.7 nTPM
spinal cord: 4.7 nTPM

Single-cell type

gonadotrophs: 63 nCPM
peritubular myoid cells: 48 nCPM
brain excitatory neurons: 40 nCPM
brain inhibitory neurons: 40 nCPM
bergmann glia: 18 nCPM
hepatocytes: 17 nCPM

Immune cell

eosinophil: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 160 nTPM
basal ganglia: 86 nTPM
white matter: 84 nTPM
hippocampal formation: 75 nTPM
amygdala: 28 nTPM
spinal cord: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 2.6
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

hydrolase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Hydrolase

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPPED1 as an antibody target. Whether an autoantibody or antibody against MPPED1 could matter depends on whether native MPPED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPPED1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPPED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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