Seroatlas · Human Serome Atlas

ACP7

Acid phosphatase type 7

Also known as: ACP7_HUMAN, FLJ16165, PAPL, PAPL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNF0
Gene: ACP7
Ensembl: ENSG00000183760
Chromosome: 19
Canonical length: 438 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>Q6ZNF0|ACP7
     1  MHPLPGYWSC YCLLLLFSLG VQGSLGAPSA APEQVHLSYP GEPGSMTVTW TTWVPTRSEV
    61  QFGLQPSGPL PLRAQGTFVP FVDGGILRRK LYIHRVTLRK LLPGVQYVYR CGSAQGWSRR
   121  FRFRALKNGA HWSPRLAVFG DLGADNPKAV PRLRRDTQQG MYDAVLHVGD FAYNLDQDNA
   181  RVGDRFMRLI EPVAASLPYM TCPGNHEERY NFSNYKARFS MPGDNEGLWY SWDLGPAHII
   241  SFSTEVYFFL HYGRHLVQRQ FRWLESDLQK ANKNRAARPW IITMGHRPMY CSNADLDDCT
   301  RHESKVRKGL QGKLYGLEDL FYKYGVDLQL WAHEHSYERL WPIYNYQVFN GSREMPYTNP
   361  RGPVHIITGS AGCEERLTPF AVFPRPWSAV RVKEYGYTRL HILNGTHIHI QQVSDDQDGK
   421  IVDDVWVVRP LFGRRMYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 10 nTPM
skin: 5.6 nTPM
tonsil: 2.4 nTPM
spinal cord: 1.9 nTPM
basal ganglia: 1.8 nTPM
hippocampal formation: 1.7 nTPM

Single-cell type

esophageal apical cells: 19 nCPM
oligodendrocytes: 11 nCPM
brain excitatory neurons: 7 nCPM
respiratory ciliated cells: 2.8 nCPM
foveolar cells: 2.7 nCPM
salivary duct cells: 2.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 14 nTPM
white matter: 8.7 nTPM
medulla oblongata: 8.4 nTPM
pons: 8.1 nTPM
midbrain: 8 nTPM
basal ganglia: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Calcineurin-like, phosphoesterase domain
Metallo-dependent phosphatase-like
Calcineurin-like phosphoesterase
Purple acid phosphatase-like, N-terminal
Purple acid phosphatase, N-terminal
Purple acid phosphatase, C-terminal domain
Purple acid phosphatase, metallophosphatase domain
Iron/zinc purple acid phosphatase-like protein C
Purple acid Phosphatase, N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACP7 as an antibody target. Whether an autoantibody or antibody against ACP7 could matter depends on whether native ACP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACP7 is annotated as secreted, so native ACP7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ACP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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