Seroatlas · Human Serome Atlas

CPPED1

Serine/threonine-protein phosphatase CPPED1

Also known as: CPPED_HUMAN, CSTP1, FLJ11151

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRF8
Gene: CPPED1
Ensembl: ENSG00000103381
Chromosome: 16
Canonical length: 314 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q9BRF8|CPPED1
     1  MSAAEAGGVF HRARGRTLAA FPAEKESEWK GPFYFILGAD PQFGLIKAWS TGDCDNGGDE
    61  WEQEIRLTEQ AVQAINKLNP KPKFFVLCGD LIHAMPGKPW RTEQTEDLKR VLRAVDRAIP
   121  LVLVSGNHDI GNTPTAETVE EFCRTWGDDY FSFWVGGVLF LVLNSQFYEN PSKCPSLKQA
   181  QDQWLDEQLS IARQRHCQHA IVFQHIPLFL ESIDEDDDYY FNLSKSTRKK LADKFIHAGV
   241  KVVFSGHYHR NAGGTYQNLD MVVSSAIGCQ LGRDPHGLRV VVVTAEKIVH RYYSLDELSE
   301  KGIEDDLMDL IKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPPED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

liver: 32 nTPM
kidney: 31 nTPM
spleen: 28 nTPM
esophagus: 24 nTPM
small intestine: 20 nTPM
duodenum: 20 nTPM

Single-cell type

neutrophils: 1,636 nCPM
esophageal apical cells: 388 nCPM
monocytes: 304 nCPM
syncytiotrophoblasts: 255 nCPM
renal collecting duct intercalated cells: 211 nCPM
sertoli cells: 203 nCPM

Immune cell

neutrophil: 676 nTPM
non-classical monocyte: 322 nTPM
intermediate monocyte: 320 nTPM
classical monocyte: 224 nTPM
myeloid DC: 169 nTPM
eosinophil: 146 nTPM

Brain region

white matter: 29 nTPM
medulla oblongata: 24 nTPM
pons: 24 nTPM
basal ganglia: 23 nTPM
hypothalamus: 22 nTPM
midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.96
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Calcineurin-like, phosphoesterase domain
Metallo-dependent phosphatase-like
Calcineurin-like phosphoesterase
CPPED1, metallophosphatase domain
Serine/threonine-protein phosphatase CPPED1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPPED1 as an antibody target. Whether an autoantibody or antibody against CPPED1 could matter depends on whether native CPPED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPPED1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPPED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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