Seroatlas · Human Serome Atlas

ACP5

Tartrate-resistant acid phosphatase type 5

Also known as: HPAP, PPA5_HUMAN, TRAcP, TRAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P13686
Gene
ACP5
Ensembl
ENSG00000102575
Chromosome
19
Canonical length
325 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>P13686|ACP5
     1  MDMWTALLIL QALLLPSLAD GATPALRFVA VGDWGGVPNA PFHTAREMAN AKEIARTVQI
    61  LGADFILSLG DNFYFTGVQD INDKRFQETF EDVFSDRSLR KVPWYVLAGN HDHLGNVSAQ
   121  IAYSKISKRW NFPSPFYRLH FKIPQTNVSV AIFMLDTVTL CGNSDDFLSQ QPERPRDVKL
   181  ARTQLSWLKK QLAAAREDYV LVAGHYPVWS IAEHGPTHCL VKQLRPLLAT YGVTAYLCGH
   241  DHNLQYLQDE NGVGYVLSGA GNFMDPSKRH QRKVPNGYLR FHYGTEDSLG GFAYVEISSK
   301  EMTVTYIEAS GKSLFKTRLP RRARP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
156 nTPM

Expression across tissuesHPA

Tissue

  • lung: 156 nTPM
  • lymph node: 67 nTPM
  • kidney: 64 nTPM
  • spleen: 53 nTPM
  • stomach: 48 nTPM
  • small intestine: 44 nTPM

Single-cell type

  • macrophages: 252 nCPM
  • esophageal apical cells: 182 nCPM
  • retinal pigment epithelial cells: 149 nCPM
  • kupffer cells: 110 nCPM
  • hofbauer cells: 83 nCPM
  • esophageal suprabasal cells: 80 nCPM

Immune cell

  • memory B-cell: 173 nTPM
  • naive B-cell: 92 nTPM
  • eosinophil: 62 nTPM
  • T-reg: 57 nTPM
  • plasmacytoid DC: 48 nTPM
  • non-classical monocyte: 32 nTPM

Brain region

  • thalamus: 27 nTPM
  • pons: 7.9 nTPM
  • white matter: 6.3 nTPM
  • hypothalamus: 3.5 nTPM
  • spinal cord: 3.3 nTPM
  • medulla oblongata: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACP5.

Disease | AllUniProt

Conditions ACP5 is implicated in, by any mechanism.

  • Spondyloenchondrodysplasia with immune dysregulation (SPENCDI) MIM:607944

Disease | GeneticClinVar

38 pathogenic / likely-pathogenic of 345 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.08
gnomAD missense Z
0.4
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACP5 as an antibody target. Whether an autoantibody or antibody against ACP5 could matter depends on whether native ACP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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