Seroatlas · Human Serome Atlas

PPP3CC

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Also known as: CALNA3, PP2BC_HUMAN, PP2Bgamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48454
Gene
PPP3CC
Ensembl
ENSG00000120910
Chromosome
8
Canonical length
512 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol,Calyx

OverviewNCBI Gene

Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>P48454|PPP3CC
     1  MSGRRFHLST TDRVIKAVPF PPTQRLTFKE VFENGKPKVD VLKNHLVKEG RLEEEVALKI
    61  INDGAAILRQ EKTMIEVDAP ITVCGDIHGQ FFDLMKLFEV GGSPSNTRYL FLGDYVDRGY
   121  FSIECVLYLW SLKINHPKTL FLLRGNHECR HLTDYFTFKQ ECRIKYSEQV YDACMETFDC
   181  LPLAALLNQQ FLCVHGGMSP EITSLDDIRK LDRFTEPPAF GPVCDLLWSD PSEDYGNEKT
   241  LEHYTHNTVR GCSYFYSYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS QATGFPSLIT
   301  IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM
   361  LVNVLNICSD DELISDDEAE GSTTVRKEII RNKIRAIGKM ARVFSILRQE SESVLTLKGL
   421  TPTGTLPLGV LSGGKQTIET ATVEAVEARE AIRGFSLQHK IRSFEEARGL DRINERMPPR
   481  KDSIHAGGPM KSVTSAHSHA AHRSDQGKKA HS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP3CC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 86 nTPM
  • retina: 72 nTPM
  • testis: 52 nTPM
  • tongue: 51 nTPM
  • heart muscle: 33 nTPM
  • blood vessel: 31 nTPM

Single-cell type

  • myonuclei: 778 nCPM
  • choroid plexus epithelial cells: 490 nCPM
  • rod photoreceptor cells: 462 nCPM
  • cone photoreceptor cells: 429 nCPM
  • thymic myoid cells: 360 nCPM
  • nk-cells: 324 nCPM

Immune cell

  • memory B-cell: 26 nTPM
  • memory CD8 T-cell: 24 nTPM
  • naive B-cell: 21 nTPM
  • NK-cell: 19 nTPM
  • memory CD4 T-cell: 19 nTPM
  • naive CD4 T-cell: 18 nTPM

Brain region

  • choroid plexus: 77 nTPM
  • cerebral cortex: 48 nTPM
  • cerebellum: 48 nTPM
  • white matter: 41 nTPM
  • thalamus: 39 nTPM
  • medulla oblongata: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.26
gnomAD missense Z
1.32
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP3CC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP3CC as an antibody target. Whether an autoantibody or antibody against PPP3CC could matter depends on whether native PPP3CC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP3CC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP3CC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP3CC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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