MPPED2
Metallophosphoesterase MPPED2
Also known as: 239FB, C11orf8, D11S302E, dJ1024C24.1, dJ873F21.1, FAM1B, Hs.46638, MPPD2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15777
- Gene
- MPPED2
- Ensembl
- ENSG00000066382
- Chromosome
- 11
- Canonical length
- 294 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Vesicles,Mitochondria
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to enable manganese ion binding activity; phosphoric diester hydrolase activity; and purine ribonucleotide binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
294 residues, UniProt reviewed canonical sequence.
>Q15777|MPPED2
1 MAHGIPSQGK VTITVDEYSS NPTQAFTHYN INQSRFQPPH VHMVDPIPYD TPKPAGHTRF
61 VCISDTHSRT DGIQMPYGDI LLHTGDFTEL GLPSEVKKFN DWLGNLPYEY KIVIAGNHEL
121 TFDKEFMADL VKQDYYRFPS VSKLKPEDFD NVQSLLTNSI YLQDSEVTVK GFRIYGAPWT
181 PWFNGWGFNL PRGQSLLDKW NLIPEGIDIL MTHGPPLGFR DWVPKELQRV GCVELLNTVQ
241 RRVRPKLHVF GGIHEGYGIM TDGYTTYINA STCTVSFQPT NPPIIFDLPN PQGSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MPPED2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 23 nTPM
Expression across tissuesHPA
Tissue
- cervix: 23 nTPM
- thyroid gland: 23 nTPM
- retina: 15 nTPM
- basal ganglia: 15 nTPM
- prostate: 12 nTPM
- pituitary gland: 9.9 nTPM
Single-cell type
- pituitary stem cells: 1,423 nCPM
- renal collecting duct intercalated cells: 1,168 nCPM
- prostatic glandular cells: 843 nCPM
- renal connecting tubule cells: 778 nCPM
- cone photoreceptor cells: 621 nCPM
- renal collecting duct principal cells: 583 nCPM
Immune cell
- MAIT T-cell: 1.8 nTPM
- NK-cell: 0.7 nTPM
- naive CD4 T-cell: 0.5 nTPM
- naive B-cell: 0.4 nTPM
- gdT-cell: 0.3 nTPM
- plasmacytoid DC: 0.2 nTPM
Brain region
- medulla oblongata: 43 nTPM
- basal ganglia: 29 nTPM
- hypothalamus: 29 nTPM
- hippocampal formation: 26 nTPM
- pons: 26 nTPM
- midbrain: 23 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.2
- gnomAD pLI
- 0.99
- gnomAD missense Z
- 2
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MPPED2 as an antibody target. Whether an autoantibody or antibody against MPPED2 could matter depends on whether native MPPED2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MPPED2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MPPED2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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