Seroatlas · Human Serome Atlas

TMPPE

Transmembrane protein with metallophosphoesterase domain

Also known as: FLJ45032, TMPPE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZT21
Gene: TMPPE
Ensembl: ENSG00000188167
Chromosome: 3
Canonical length: 453 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable hydrolase activity and metal ion binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q6ZT21|TMPPE
     1  MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL FVNSLLLIGS
    61  LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF FTMFFLVAEE PYLFSLAAYS
   121  CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG RVVGSLEKTR KLVLRPALAV GVTAVLSVAG
   181  ILNAAQPPAV KTVEVPIHQL PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI
   241  TVIVGDLSDS EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL
   301  HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD LDKALEGCSP
   361  DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL NVAAYLLNPF FAGLYQVAQA
   421  TFVYVSPGTA YYGIPMRLGS RAEITELILQ RSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPPE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.2 nTPM
retina: 2.6 nTPM
parathyroid gland: 1.8 nTPM
spleen: 1.4 nTPM
appendix: 1.3 nTPM
duodenum: 1.2 nTPM

Single-cell type

foveolar cells: 0.4 nCPM
colonocytes: 0.1 nCPM
salivary duct cells: 0.1 nCPM
vascular endothelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

intermediate monocyte: 2.4 nTPM
neutrophil: 1.9 nTPM
classical monocyte: 1.1 nTPM
non-classical monocyte: 1.1 nTPM
myeloid DC: 1 nTPM
MAIT T-cell: 0.6 nTPM

Brain region

choroid plexus: 19 nTPM
thalamus: 14 nTPM
pons: 14 nTPM
midbrain: 13 nTPM
hippocampal formation: 13 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 1.08
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Calcineurin-like, phosphoesterase domain
Metallo-dependent phosphatase-like
Calcineurin-like phosphoesterase
Metallophosphoesterase-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPPE as an antibody target. Whether an autoantibody or antibody against TMPPE could matter depends on whether native TMPPE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPPE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMPPE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...