Seroatlas · Human Serome Atlas

ABLIM1

Actin-binding LIM protein 1

Also known as: ABLIM, ABLM1_HUMAN, LIMAB1, limatin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14639
Gene: ABLIM1
Ensembl: ENSG00000099204
Chromosome: 10
Canonical length: 778 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol,Connecting piece,Mid piece

OverviewNCBI Gene

This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2017]

Canonical amino-acid sequenceUniProt

778 residues, UniProt reviewed canonical sequence.

>O14639|ABLIM1
     1  MPAFLGLKCL GKLCSSEKSK VTSSERTSAR GSNRKRLIVE DRRVSGTSFT AHRRATITHL
    61  LYLCPKDYCP RGRVCNSVDP FVAHPQDPHH PSEKPVIHCH KCGEPCKGEV LRVQTKHFHI
   121  KCFTCKVCGC DLAQGGFFIK NGEYLCTLDY QRMYGTRCHG CGEFVEGEVV TALGKTYHPN
   181  CFACTICKRP FPPGDRVTFN GRDCLCQLCA QPMSSSPKET TFSSNCAGCG RDIKNGQALL
   241  ALDKQWHLGC FKCKSCGKVL TGEYISKDGA PYCEKDYQGL FGVKCEACHQ FITGKVLEAG
   301  DKHYHPSCAR CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRPTR TSSESIYSRP
   361  GSSIPGSPGH TIYAKVDNEI LDYKDLAAIP KVKAIYDIER PDLITYEPFY TSGYDDKQER
   421  QSLGESPRTL SPTPSAEGYQ DVRDRMIHRS TSQGSINSPV YSRHSYTPTT SRSPQHFHRP
   481  GNEPSSGRNS PLPYRPDSRP LTPTYAQAPK HFHVPDQGIN IYRKPPIYKQ HAALAAQSKS
   541  SEDIIKFSKF PAAQAPDPSE TPKIETDHWP GPPSFAVVGP DMKRRSSGRE EDDEELLRRR
   601  QLQEEQLMKL NSGLGQLILK EEMEKESRER SSLLASRYDS PINSASHIPS SKTASLPGYG
   661  RNGLHRPVST DFAQYNSYGD VSGGVRDYQT LPDGHMPAMR MDRGVSMPNM LEPKIFPYEM
   721  LMVTNRGRNK ILREVDRTRL ERHLAPEVFR EIFGMSIQEF DRLPLWRRND MKKKAKLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABLIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 279 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 279 nTPM
cerebellum: 272 nTPM
esophagus: 185 nTPM
ovary: 178 nTPM
stomach: 112 nTPM
thyroid gland: 104 nTPM

Single-cell type

esophageal apical cells: 2,697 nCPM
cardiomyocytes: 2,310 nCPM
adrenal cortex cells: 1,542 nCPM
astrocytes: 1,411 nCPM
foveolar cells: 1,084 nCPM
thymic myoid cells: 1,028 nCPM

Immune cell

naive CD4 T-cell: 139 nTPM
naive CD8 T-cell: 91 nTPM
NK-cell: 64 nTPM
MAIT T-cell: 55 nTPM
memory CD4 T-cell: 54 nTPM
naive B-cell: 52 nTPM

Brain region

cerebellum: 597 nTPM
medulla oblongata: 207 nTPM
spinal cord: 203 nTPM
choroid plexus: 193 nTPM
hypothalamus: 184 nTPM
white matter: 173 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.93
gnomAD missense Z: 1.62
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABLIM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABLIM1 as an antibody target. Whether an autoantibody or antibody against ABLIM1 could matter depends on whether native ABLIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABLIM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABLIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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