Seroatlas · Human Serome Atlas

TESK1

Dual specificity testis-specific protein kinase 1

Also known as: TESK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15569
Gene
TESK1
Ensembl
ENSG00000107140
Chromosome
9
Canonical length
626 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q15569|TESK1
     1  MAGERPPLRG PGPGPGEVPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS LARVDDFHCA
    61  EKIGAGFFSE VYKVRHRQSG QVMVLKMNKL PSNRGNTLRE VQLMNRLRHP NILRFMGVCV
   121  HQGQLHALTE YMNGGTLEQL LSSPEPLSWP VRLHLALDIA RGLRYLHSKG VFHRDLTSKN
   181  CLVRREDRGF TAVVGDFGLA EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV
   241  FAFGIVLCEL IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCNLEPST
   301  RAPFTEITQH LEWILEQLPE PAPLTRTALT HNQGSVARGG PSATLPRPDP RLSRSRSDLF
   361  LPPSPESPPN WGDNLTRVNP FSLREDLRGG KIKLLDTPSK PVLPLVPPSP FPSTQLPLVT
   421  TPETLVQPGT PARRCRSLPS SPELPRRMET ALPGPGPPAV GPSAEEKMEC EGSSPEPEPP
   481  GPAPQLPLAV ATDNFISTCS SASQPWSPRS GPVLNNNPPA VVVNSPQGWA GEPWNRAQHS
   541  LPRAAALERT EPSPPPSAPR EPDEGLPCPG CCLGPFSFGF LSMCPRPTPA VARYRNLNCE
   601  AGSLLCHRGH HAKPPTPSLQ LPGARS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TESK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 62 nTPM
  • testis: 51 nTPM
  • blood vessel: 47 nTPM
  • adrenal gland: 37 nTPM
  • adipose tissue: 34 nTPM
  • cerebral cortex: 31 nTPM

Single-cell type

  • late spermatids: 47 nCPM
  • early spermatids: 44 nCPM
  • alveolar cells type 1: 26 nCPM
  • vascular smooth muscle cells: 22 nCPM
  • pancreatic islet cells: 21 nCPM
  • innate lymphoid cells: 19 nCPM

Immune cell

  • memory CD8 T-cell: 1.8 nTPM
  • gdT-cell: 1.1 nTPM
  • MAIT T-cell: 1 nTPM
  • NK-cell: 0.9 nTPM
  • myeloid DC: 0.8 nTPM
  • plasmacytoid DC: 0.8 nTPM

Brain region

  • thalamus: 46 nTPM
  • cerebral cortex: 40 nTPM
  • amygdala: 38 nTPM
  • midbrain: 38 nTPM
  • pons: 33 nTPM
  • basal ganglia: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
1.61
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TESK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TESK1 as an antibody target. Whether an autoantibody or antibody against TESK1 could matter depends on whether native TESK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TESK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TESK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TESK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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