Seroatlas · Human Serome Atlas

SYNPO2

Synaptopodin-2

Also known as: MYOPODIN, SYISL, SYNP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UMS6
Gene
SYNPO2
Ensembl
ENSG00000172403
Chromosome
4
Canonical length
1093 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Actin filaments

OverviewNCBI Gene

Enables alpha-actinin binding activity and filamin binding activity. Involved in positive regulation of actin filament bundle assembly; positive regulation of cell migration; and regulation of Rho-dependent protein serine/threonine kinase activity. Located in several cellular components, including Z disc; focal adhesion; and stress fiber. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1093 residues, UniProt reviewed canonical sequence.

>Q9UMS6|SYNPO2
     1  MGTGDFICIS MTGGAPWGFR LQGGKEQKQP LQVAKIRNQS KASGSGLCEG DEVVSINGNP
    61  CADLTYPEVI KLMESITDSL QMLIKRPSSG ISEALISENE NKNLEHLTHG GYVESTTLQI
   121  RPATKTQCTE FFLAPVKTEV PLAENQRSGP DCAGSLKEET GPSYQRAPQM PDSQRGRVAE
   181  ELILREKVEA VQPGPVVELQ LSLSQERHKG ASGPLVALPG AEKSKSPDPD PNLSHDRIVH
   241  INSIPTNEKA DPFLRSSKII QISSGRELRV IQESEAGDAG LPRVEVILDC SDRQKTEGCR
   301  LQAGKECVDS PVEGGQSEAP PSLVSFAVSS EGTEQGEDPR SEKDHSRPHK HRARHARLRR
   361  SESLSEKQVK EAKSKCKSIA LLLTDAPNPN SKGVLMFKKR RRRARKYTLV SYGTGELERE
   421  ADEEEEGDKE DTCEVAFLGA SESEVDEELL SDVDDNTQVV NFDWDSGLVD IEKKLNRGDK
   481  MEMLPDTTGK GALMFAKRRE RMDQITAQKE EDKVGGTPSR EQDAAQTDGL RTTTSYQRKE
   541  EESVRTQSSV SKSYIEVSHG LGHVPQQNGF SGTSETANIQ RMVPMNRTAK PFPGSVNQPA
   601  TPFSPTRNMT SPIADFPAPP PYSAVTPPPD AFSRGVSSPI AGPAQPPPWP QPAPWSQPAF
   661  YDSSERIASR DERISVPAKR TGILQEAKRR STTKPMFTFK EPKVSPNPEL LSLLQNSEGK
   721  RGTGAGGDSG PEEDYLSLGA EACNFMQSSS AKQKTPPPVA PKPAVKSSSS QPVTPVSPVW
   781  SPGVAPTQPP AFPTSNPSKG TVVSSIKIAQ PSYPPARPAS TLNVAGPFKG PQAAVASQNY
   841  TPKPTVSTPT VNAVQPGAVG PSNELPGMSG RGAQLFAKRQ SRMEKYVVDS DTVQAHAARA
   901  QSPTPSLPAS WKYSSNVRAP PPVAYNPIHS PSYPLAALKS QPSAAQPSKM GKKKGKKPLN
   961  ALDVMKHQPY QLNASLFTFQ PPDAKDGLPQ KSSVKVNSAL AMKQALPPRP VNAASPTNVQ
  1021  ASSVYSVPAY TSPPSFFAEA SSPVSASPVP VGIPTSPKQE SASSSYFVAP RPKFSAKKSG
  1081  VTIQVWKPSV VEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNPO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
952 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 952 nTPM
  • tongue: 461 nTPM
  • blood vessel: 287 nTPM
  • colon: 277 nTPM
  • seminal vesicle: 252 nTPM
  • smooth muscle: 228 nTPM

Single-cell type

  • smooth muscle cells: 2,285 nCPM
  • thymic myoid cells: 1,515 nCPM
  • cardiomyocytes: 1,047 nCPM
  • myonuclei: 975 nCPM
  • vascular smooth muscle cells: 814 nCPM
  • sertoli cells: 588 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • eosinophil: 0.5 nTPM
  • T-reg: 0.5 nTPM
  • MAIT T-cell: 0.4 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • naive B-cell: 0.4 nTPM

Brain region

  • hypothalamus: 44 nTPM
  • white matter: 40 nTPM
  • hippocampal formation: 37 nTPM
  • spinal cord: 35 nTPM
  • cerebral cortex: 32 nTPM
  • basal ganglia: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
0.04
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYNPO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNPO2 as an antibody target. Whether an autoantibody or antibody against SYNPO2 could matter depends on whether native SYNPO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNPO2 is annotated at the cell surface, where native SYNPO2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYNPO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYNPO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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