Seroatlas · Human Serome Atlas

PAXIP1

PAX-interacting protein 1

Also known as: CAGF28, CAGF29, PAXI1_HUMAN, PAXIP1L, PTIP, TNRC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZW49
Gene: PAXIP1
Ensembl: ENSG00000157212
Chromosome: 7
Canonical length: 1069 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1069 residues, UniProt reviewed canonical sequence.

>Q6ZW49|PAXIP1
     1  MSDQAPKVPE EMFREVKYYA VGDIDPQVIQ LLKAGKAKEV SYNALASHII SEDGDNPEVG
    61  EAREVFDLPV VKPSWVILSV QCGTLLPVNG FSPESCQIFF GITACLSQVS SEDRSALWAL
   121  VTFYGGDCQL TLNKKCTHLI VPEPKGEKYE CALKRASIKI VTPDWVLDCV SEKTKKDEAF
   181  YHPRLIIYEE EEEEEEEEEE VENEEQDSQN EGSTDEKSSP ASSQEGSPSG DQQFSPKSNT
   241  EKSKGELMFD DSSDSSPEKQ ERNLNWTPAE VPQLAAAKRR LPQGKEPGLI NLCANVPPVP
   301  GNILPPEVRG NLMAAGQNLQ SSERSEMIAT WSPAVRTLRN ITNNADIQQM NRPSNVAHIL
   361  QTLSAPTKNL EQQVNHSQQG HTNANAVLFS QVKVTPETHM LQQQQQAQQQ QQQHPVLHLQ
   421  PQQIMQLQQQ QQQQISQQPY PQQPPHPFSQ QQQQQQQAHP HQFSQQQLQF PQQQLHPPQQ
   481  LHRPQQQLQP FQQQHALQQQ FHQLQQHQLQ QQQLAQLQQQ HSLLQQQQQQ QIQQQQLQRM
   541  HQQQQQQQMQ SQTAPHLSQT SQALQHQVPP QQPPQQQQQQ QPPPSPQQHQ LFGHDPAVEI
   601  PEEGFLLGCV FAIADYPEQM SDKQLLATWK RIIQAHGGTV DPTFTSRCTH LLCESQVSSA
   661  YAQAIRERKR CVTAHWLNTV LKKKKMVPPH RALHFPVAFP PGGKPCSQHI ISVTGFVDSD
   721  RDDLKLMAYL AGAKYTGYLC RSNTVLICKE PTGLKYEKAK EWRIPCVNAQ WLGDILLGNF
   781  EALRQIQYSR YTAFSLQDPF APTQHLVLNL LDAWRVPLKV SAELLMSIRL PPKLKQNEVA
   841  NVQPSSKRAR IEDVPPPTKK LTPELTPFVL FTGFEPVQVQ QYIKKLYILG GEVAESAQKC
   901  THLIASKVTR TVKFLTAISV VKHIVTPEWL EECFRCQKFI DEQNYILRDA EAEVLFSFSL
   961  EESLKRAHVS PLFKAKYFYI TPGICPSLST MKAIVECAGG KVLSKQPSFR KLMEHKQNSS
  1021  LSEIILISCE NDLHLCREYF ARGIDVHNAE FVLTGVLTQT LDYESYKFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAXIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

thymus: 25 nTPM
cerebellum: 21 nTPM
bone marrow: 9.3 nTPM
lymph node: 8.2 nTPM
testis: 8.1 nTPM
skin: 6.2 nTPM

Single-cell type

epicardial cells: 73 nCPM
brain excitatory neurons: 57 nCPM
erythrocyte progenitors: 55 nCPM
early primary spermatocytes: 51 nCPM
myonuclei: 42 nCPM
thyrotrophs: 41 nCPM

Immune cell

naive CD4 T-cell: 2.4 nTPM
memory CD4 T-cell: 1.5 nTPM
MAIT T-cell: 1.4 nTPM
NK-cell: 1.3 nTPM
non-classical monocyte: 1.3 nTPM
plasmacytoid DC: 1.3 nTPM

Brain region

cerebellum: 22 nTPM
pons: 2.3 nTPM
cerebral cortex: 2 nTPM
medulla oblongata: 1.9 nTPM
white matter: 1.9 nTPM
choroid plexus: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 3.28
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAXIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAXIP1 as an antibody target. Whether an autoantibody or antibody against PAXIP1 could matter depends on whether native PAXIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAXIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAXIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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