Seroatlas · Human Serome Atlas

FAM199X

Protein FAM199X

Also known as: CXorf39, F199X_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PEV8
Gene: FAM199X
Ensembl: ENSG00000123575
Chromosome: X
Canonical length: 388 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

No narrative summary is available for FAM199X in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q6PEV8|FAM199X
     1  MSDEASAITS YEKFLTPEEP FPLLGPPRGV GTCPSEEPGC LDISDFGCQL SSCHRTDPLH
    61  RFHTNRWNLT SCGTSVASSE GSEELFSSVS VGDQDDCYSL LDDQDFTSFD LFPEGSVCSD
   121  VSSSISTYWD WSDSEFEWQL PGSDIASGSD VLSDVIPSIP SSPCLLPKKK NKHRNLDELP
   181  WSAMTNDEQV EYIEYLSRKV STEMGLREQL DIIKIIDPSA QISPTDSEFI IELNCLTDEK
   241  LKQVRNYIKE HSPRQRPARE AWKRSNFSCA STSGVSGASA SASSSSASMV SSASSSGSSV
   301  GNSASNSSAN MSRAHSDSNL SASAAERIRD SKKRSKQRKL QQKAFRKRQL KEQRQARKER
   361  LSGLFLNEEV LSLKVTEEDH EADVDVLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM199X can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

epididymis: 33 nTPM
cerebral cortex: 21 nTPM
adipose tissue: 19 nTPM
parathyroid gland: 19 nTPM
thyroid gland: 16 nTPM
retina: 15 nTPM

Single-cell type

adipocytes: 80 nCPM
sertoli cells: 79 nCPM
epididymal principal cells: 75 nCPM
podocytes: 75 nCPM
renal collecting duct principal cells: 65 nCPM
corticotrophs: 59 nCPM

Immune cell

naive B-cell: 1.3 nTPM
naive CD4 T-cell: 0.9 nTPM
memory CD8 T-cell: 0.8 nTPM
T-reg: 0.8 nTPM
gdT-cell: 0.7 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

thalamus: 44 nTPM
midbrain: 42 nTPM
hypothalamus: 41 nTPM
white matter: 40 nTPM
cerebellum: 39 nTPM
pons: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.57
gnomAD missense Z: 2.5
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

FAM199X family
Protein family FAM199X

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of FAM199X in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

WDR5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM199X as an antibody target. Whether an autoantibody or antibody against FAM199X could matter depends on whether native FAM199X is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM199X is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM199X as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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