Seroatlas · Human Serome Atlas

BOD1L1

Biorientation of chromosomes in cell division protein 1-like 1

Also known as: BD1L1_HUMAN, BOD1L, FAM44A, FLJ33215, KIAA1327

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFC6
Gene: BOD1L1
Ensembl: ENSG00000038219
Chromosome: 4
Canonical length: 3051 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in DNA damage response and replication fork processing. Located in nucleoplasm. Part of Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

3051 residues, UniProt reviewed canonical sequence.

>Q8NFC6|BOD1L1
     1  MATNPQPQPP PPAPPPPPPQ PQPQPPPPPP GPGAGPGAGG AGGAGAGAGD PQLVAMIVNH
    61  LKSQGLFDQF RRDCLADVDT KPAYQNLRQR VDNFVANHLA THTWSPHLNK NQLRNNIRQQ
   121  VLKSGMLESG IDRIISQVVD PKINHTFRPQ VEKAVHEFLA TLNHKEEGSG NTAPDDEKPD
   181  TSLITQGVPT PGPSANVAND AMSILETITS LNQEASAARA STETSNAKTS ERASKKLPSQ
   241  PTTDTSTDKE RTSEDMADKE KSTADSGGEG LETAPKSEEF SDLPCPVEEI KNYTKEHNNL
   301  ILLNKDVQQE SSEQKNKSTD KGEKKPDSNE KGERKKEKKE KTEKKFDHSK KSEDTQKVKD
   361  EKQAKEKEVE SLKLPSEKNS NKAKTVEGTK EDFSLIDSDV DGLTDITVSS VHTSDLSSFE
   421  EDTEEEVVTS DSMEEGEITS DDEEKNKQNK TKTQTSDSSE GKTKSVRHAY VHKPYLYSKY
   481  YSDSDDELTV EQRRQSIAKE KEERLLRRQI NREKLEEKRK QKAEKTKSSK TKGQGRSSVD
   541  LEESSTKSLE PKAARIKEVL KERKVLEKKV ALSKKRKKDS RNVEENSKKK QQYEEDSKET
   601  LKTSEHCEKE KISSSKELKH VHAKSEPSKP ARRLSESLHV VDENKNESKL EREHKRRTST
   661  PVIMEGVQEE TDTRDVKRQV ERSEICTEEP QKQKSTLKNE KHLKKDDSET PHLKSLLKKE
   721  VKSSKEKPER EKTPSEDKLS VKHKYKGDCM HKTGDETELH SSEKGLKVEE NIQKQSQQTK
   781  LSSDDKTERK SKHRNERKLS VLGKDGKPVS EYIIKTDENV RKENNKKERR LSAEKTKAEH
   841  KSRRSSDSKI QKDSLGSKQH GITLQRRSES YSEDKCDMDS TNMDSNLKPE EVVHKEKRRT
   901  KSLLEEKLVL KSKSKTQGKQ VKVVETELQE GATKQATTPK PDKEKNTEEN DSEKQRKSKV
   961  EDKPFEETGV EPVLETASSS AHSTQKDSSH RAKLPLAKEK YKSDKDSTST RLERKLSDGH
  1021  KSRSLKHSSK DIKKKDENKS DDKDGKEVDS SHEKARGNSS LMEKKLSRRL CENRRGSLSQ
  1081  EMAKGEEKLA ANTLSTPSGS SLQRPKKSGD MTLIPEQEPM EIDSEPGVEN VFEVSKTQDN
  1141  RNNNSQQDID SENMKQKTSA TVQKDELRTC TADSKATAPA YKPGRGTGVN SNSEKHADHR
  1201  STLTKKMHIQ SAVSKMNPGE KEPIHRGTTE VNIDSETVHR MLLSAPSEND RVQKNLKNTA
  1261  AEEHVAQGDA TLEHSTNLDS SPSLSSVTVV PLRESYDPDV IPLFDKRTVL EGSTASTSPA
  1321  DHSALPNQSL TVRESEVLKT SDSKEGGEGF TVDTPAKASI TSKRHIPEAH QATLLDGKQG
  1381  KVIMPLGSKL TGVIVENENI TKEGGLVDMA KKENDLNAEP NLKQTIKATV ENGKKDGIAV
  1441  DHVVGLNTEK YAETVKLKHK RSPGKVKDIS IDVERRNENS EVDTSAGSGS APSVLHQRNG
  1501  QTEDVATGPR RAEKTSVATS TEGKDKDVTL SPVKAGPATT TSSETRQSEV ALPCTSIEAD
  1561  EGLIIGTHSR NNPLHVGAEA SECTVFAAAE EGGAVVTEGF AESETFLTST KEGESGECAV
  1621  AESEDRAADL LAVHAVKIEA NVNSVVTEEK DDAVTSAGSE EKCDGSLSRD SEIVEGTITF
  1681  ISEVESDGAV TSAGTEIRAG SISSEEVDGS QGNMMRMGPK KETEGTVTCT GAEGRSDNFV
  1741  ICSVTGAGPR EERMVTGAGV VLGDNDAPPG TSASQEGDGS VNDGTEGESA VTSTGITEDG
  1801  EGPASCTGSE DSSEGFAISS ESEENGESAM DSTVAKEGTN VPLVAAGPCD DEGIVTSTGA
  1861  KEEDEEGEDV VTSTGRGNEI GHASTCTGLG EESEGVLICE SAEGDSQIGT VVEHVEAEAG
  1921  AAIMNANENN VDSMSGTEKG SKDTDICSSA KGIVESSVTS AVSGKDEVTP VPGGCEGPMT
  1981  SAASDQSDSQ LEKVEDTTIS TGLVGGSYDV LVSGEVPECE VAHTSPSEKE DEDIITSVEN
  2041  EECDGLMATT ASGDITNQNS LAGGKNQGKV LIISTSTTND YTPQVSAITD VEGGLSDALR
  2101  TEENMEGTRV TTEEFEAPMP SAVSGDDSQL TASRSEEKDE CAMISTSIGE EFELPISSAT
  2161  TIKCAESLQP VAAAVEERAT GPVLISTADF EGPMPSAPPE AESPLASTSK EEKDECALIS
  2221  TSIAEECEAS VSGVVVESEN ERAGTVMEEK DGSGIISTSS VEDCEGPVSS AVPQEEGDPS
  2281  VTPAEEMGDT AMISTSTSEG CEAVMIGAVL QDEDRLTITR VEDLSDAAII STSTAECMPI
  2341  SASIDRHEEN QLTADNPEGN GDLSATEVSK HKVPMPSLIA ENNCRCPGPV RGGKEPGPVL
  2401  AVSTEEGHNG PSVHKPSAGQ GHPSAVCAEK EEKHGKECPE IGPFAGRGQK ESTLHLINAE
  2461  EKNVLLNSLQ KEDKSPETGT AGGSSTASYS AGRGLEGNAN SPAHLRGPEQ TSGQTAKDPS
  2521  VSIRYLAAVN TGAIKADDMP PVQGTVAEHS FLPAEQQGSE DNLKTSTTKC ITGQESKIAP
  2581  SHTMIPPATY SVALLAPKCE QDLTIKNDYS GKWTDQASAE KTGDDNSTRK SFPEEGDIMV
  2641  TVSSEENVCD IGNEESPLNV LGGLKLKANL KMEAYVPSEE EKNGEILAPP ESLCGGKPSG
  2701  IAELQREPLL VNESLNVENS GFRTNEEIHS ESYNKGEISS GRKDNAEAIS GHSVEADPKE
  2761  VEEEERHMPK RKRKQHYLSS EDEPDDNPDV LDSRIETAQR QCPETEPHDT KEENSRDLEE
  2821  LPKTSSETNS TTSRVMEEKD EYSSSETTGE KPEQNDDDTI KSQEEDQPII IKRKRGRPRK
  2881  YPVETTLKMK DDSKTDTGIV TVEQSPSSSK LKVMQTDESN KETANLQERS ISNDDGEEKI
  2941  VTSVRRRGRK PKRSLTVSDD AESSEPERKR QKSVSDPVED KKEQESDEEE EEEEEDEPSG
  3001  ATTRSTTRSE AQRSKTQLSP SIKRKREVSP PGARTRGQQR VEEAPVKKAK R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BOD1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 21 nTPM
spleen: 21 nTPM
ovary: 20 nTPM
cerebellum: 18 nTPM
small intestine: 18 nTPM
endometrium: 16 nTPM

Single-cell type

neutrophils: 913 nCPM
sertoli cells: 428 nCPM
neutrophil progenitors: 246 nCPM
endometrial glandular cells: 203 nCPM
endometrial luminal cells: 199 nCPM
b-cells: 190 nCPM

Immune cell

neutrophil: 8.4 nTPM
basophil: 2.7 nTPM
eosinophil: 2 nTPM
plasmacytoid DC: 1.6 nTPM
naive B-cell: 1.4 nTPM
memory B-cell: 1.1 nTPM

Brain region

cerebellum: 37 nTPM
white matter: 32 nTPM
cerebral cortex: 31 nTPM
hypothalamus: 31 nTPM
medulla oblongata: 29 nTPM
basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BOD1L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BOD1L1 as an antibody target. Whether an autoantibody or antibody against BOD1L1 could matter depends on whether native BOD1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BOD1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BOD1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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