Seroatlas · Human Serome Atlas

MEN1

Menin

Also known as: MEN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00255
Gene
MEN1
Ensembl
ENSG00000133895
Chromosome
11
Canonical length
610 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>O00255|MEN1
     1  MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE
    61  LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK
   121  VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED
   181  HAWVVFGPNG EQTAEVTWHG KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV
   241  CAINPSIDLH TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT
   301  LYHKGIASAK TYYRDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI
   361  YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQSQGTQSQ GSALQDPECF AHLLRFYDGI
   421  CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVRIVSR EAEAAEAEEP WGEEAREGRR
   481  RGPRRESKPE EPPPPKKPAL DKGLGTGQGA VSGPPRKPPG TVAGTARGPE GGSTAQVPAP
   541  TASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL
   601  SFLKRQRKGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • liver: 22 nTPM
  • adrenal gland: 18 nTPM
  • cerebral cortex: 18 nTPM
  • pancreas: 18 nTPM
  • thymus: 17 nTPM
  • choroid plexus: 17 nTPM

Single-cell type

  • megakaryocytes: 37 nCPM
  • extravillous trophoblasts: 26 nCPM
  • cytotrophoblasts: 23 nCPM
  • tuft cells: 23 nCPM
  • migrating cytotrophoblasts: 22 nCPM
  • differentiating spermatogonia: 19 nCPM

Immune cell

  • memory B-cell: 2.2 nTPM
  • MAIT T-cell: 2.1 nTPM
  • memory CD8 T-cell: 2.1 nTPM
  • naive CD4 T-cell: 2.1 nTPM
  • naive B-cell: 1.9 nTPM
  • gdT-cell: 1.7 nTPM

Brain region

  • cerebral cortex: 22 nTPM
  • basal ganglia: 20 nTPM
  • thalamus: 19 nTPM
  • hippocampal formation: 18 nTPM
  • amygdala: 18 nTPM
  • choroid plexus: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MEN1.

Disease | AllUniProt

Conditions MEN1 is implicated in, by any mechanism.

  • Familial multiple endocrine neoplasia type I (MEN1) MIM:131100

Disease | GeneticClinVar

678 pathogenic / likely-pathogenic of 3,115 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
3.25
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Menin
  • Menin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEN1 as an antibody target. Whether an autoantibody or antibody against MEN1 could matter depends on whether native MEN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MEN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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