Seroatlas · Human Serome Atlas

ZXDC

Zinc finger protein ZXDC

Also known as: FLJ13861, MGC11349, ZXDC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2QGD7
Gene: ZXDC
Ensembl: ENSG00000070476
Chromosome: 3
Canonical length: 858 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Involved in positive regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

858 residues, UniProt reviewed canonical sequence.

>Q2QGD7|ZXDC
     1  MDLPALLPAP TARGGQHGGG PGPLRRAPAP LGASPARRRL LLVRGPEDGG PGARPGEASG
    61  PSPPPAEDDS DGDSFLVLLE VPHGGAAAEA AGSQEAEPGS RVNLASRPEQ GPSGPAAPPG
   121  PGVAPAGAVT ISSQDLLVRL DRGVLALSAP PGPATAGAAA PRRAPQASGP STPGYRCPEP
   181  QCALAFAKKH QLKVHLLTHG GGQGRRPFKC PLEGCGWAFT TSYKLKRHLQ SHDKLRPFGC
   241  PVGGCGKKFT TVYNLKAHMK GHEQESLFKC EVCAERFPTH AKLSSHQRSH FEPERPYKCD
   301  FPGCEKTFIT VSALFSHNRA HFREQELFSC SFPGCSKQYD KACRLKIHLR SHTGERPFIC
   361  DSDSCGWTFT SMSKLLRHRR KHDDDRRFTC PVEGCGKSFT RAEHLKGHSI THLGTKPFEC
   421  PVEGCCARFS ARSSLYIHSK KHVQDVGAPK SRCPVSTCNR LFTSKHSMKA HMVRQHSRRQ
   481  DLLPQLEAPS SLTPSSELSS PGQSELTNMD LAALFSDTPA NASGSAGGSD EALNSGILTI
   541  DVTSVSSSLG GNLPANNSSL GPMEPLVLVA HSDIPPSLDS PLVLGTAATV LQQGSFSVDD
   601  VQTVSAGALG CLVALPMKNL SDDPLALTSN SNLAAHITTP TSSSTPRENA SVPELLAPIK
   661  VEPDSPSRPG AVGQQEGSHG LPQSTLPSPA EQHGAQDTEL SAGTGNFYLE SGGSARTDYR
   721  AIQLAKEKKQ RGAGSNAGAS QSTQRKIKEG KMSPPHFHAS QNSWLCGSLV VPSGGRPGPA
   781  PAAGVQCGAQ GVQVQLVQDD PSGEGVLPSA RGPATFLPFL TVDLPVYVLQ EVLPSSGGPA
   841  GPEATQFPGS TINLQDLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZXDC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 37 nTPM
skeletal muscle: 15 nTPM
pancreas: 14 nTPM
parathyroid gland: 9.5 nTPM
thymus: 9.3 nTPM
skin: 9.1 nTPM

Single-cell type

myonuclei: 292 nCPM
neutrophil progenitors: 222 nCPM
neutrophils: 216 nCPM
gonadotrophs: 139 nCPM
bergmann glia: 136 nCPM
proximal tubule cells: 135 nCPM

Immune cell

non-classical monocyte: 4.4 nTPM
basophil: 1.7 nTPM
neutrophil: 1.2 nTPM
plasmacytoid DC: 1.1 nTPM
eosinophil: 0.8 nTPM
myeloid DC: 0.7 nTPM

Brain region

white matter: 47 nTPM
medulla oblongata: 40 nTPM
cerebral cortex: 39 nTPM
choroid plexus: 38 nTPM
basal ganglia: 38 nTPM
midbrain: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 1.38
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZXDC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZXDC as an antibody target. Whether an autoantibody or antibody against ZXDC could matter depends on whether native ZXDC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZXDC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZXDC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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