Seroatlas · Human Serome Atlas

ZNF335

Zinc finger protein 335

Also known as: bA465L10.2, NIF-1, ZN335_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4Z2
Gene: ZNF335
Ensembl: ENSG00000198026
Chromosome: 20
Canonical length: 1342 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1342 residues, UniProt reviewed canonical sequence.

>Q9H4Z2|ZNF335
     1  MEENEVESSS DAAPGPGRPE EPSESGLGVG TSEAVSADSS DAAAAPGQAE ADDSGVGQSS
    61  DRGSRSQEEV SESSSSADPL PNSYLPDSSS VSHGPVAGVT GGPPALVHSS ALPDPNMLVS
   121  DCTASSSDLG SAIDKIIEST IGPDLIQNCI TVTSAEDGGA ETTRYLILQG PDDGAPMTSP
   181  MSSSTLAHSL AAIEALADGP TSTSTCLEAQ GGPSSPVQLP PASGAEEPDL QSLEAMMEVV
   241  VVQQFKCKMC QYRSSTKATL LRHMRERHFR PVAAAAAAAG KKGRLRKWST STKSQEEEGP
   301  EEEDDDDIVD AGAIDDLEED SDYNPAEDEP RGRQLRLQRP TPSTPRPRRR PGRPRKLPRL
   361  EISDLPDGVE GEPLVSSQSG QSPPEPQDPE APSSSGPGHL VAMGKVSRTP VEAGVSQSDA
   421  ENAAPSCPDE HDTLPRRRGR PSRRFLGKKY RKYYYKSPKP LLRPFLCRIC GSRFLSHEDL
   481  RFHVNSHEAG DPQLFKCLQC SYRSRRWSSL KEHMFNHVGS KPYKCDECSY TSVYRKDVIR
   541  HAAVHSRDRK KRPDPTPKLS SFPCPVCGRV YPMQKRLTQH MKTHSTEKPH MCDKCGKSFK
   601  KRYTFKMHLL THIQAVANRR FKCEFCEFVC EDKKALLNHQ LSHVSDKPFK CSFCPYRTFR
   661  EDFLLSHVAV KHTGAKPFAC EYCHFSTRHK KNLRLHVRCR HASSFEEWGR RHPEEPPSRR
   721  RPFFSLQQIE ELKQQHSAAP GPPPSSPGPP EIPPEATTFQ SSEAPSLLCS DTLGGATIIY
   781  QQGAEESTAM ATQTALDLLL NMSAQRELGG TALQVAVVKS EDVEAGLASP GGQPSPEGAT
   841  PQVVTLHVAE PGGGAAAESQ LGPPDLPQIT LAPGPFGGTG YSVITAPPME EGTSAPGTPY
   901  SEEPAGEAAQ AVVVSDTLKE AGTHYIMATD GTQLHHIELT ADGSISFPSP DALASGAKWP
   961  LLQCGGLPRD GPEPPSPAKT HCVGDSQSSA SSPPATSKAL GLAVPPSPPS AATAASKKFS
  1021  CKICAEAFPG RAEMESHKRA HAGPGAFKCP DCPFSARQWP EVRAHMAQHS SLRPHQCSQC
  1081  SFASKNKKDL RRHMLTHTKE KPFACHLCGQ RFNRNGHLKF HIQRLHSPDG RKSGTPTARA
  1141  PTQTPTQTII LNSDDETLAT LHTALQSSHG VLGPERLQQA LSQEHIIVAQ EQTVTNQEEA
  1201  AYIQEITTAD GQTVQHLVTS DNQVQYIISQ DGVQHLLPQE YVVVPEGHHI QVQEGQITHI
  1261  QYEQGAPFLQ ESQIQYVPVS PGQQLVTQAQ LEAAAHSAVT AVADAAMAQA QGLFGTDETV
  1321  PEHIQQLQHQ GIEYDVITLA DD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF335 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 28 nTPM
cerebellum: 24 nTPM
spleen: 21 nTPM
skin: 20 nTPM
ovary: 17 nTPM
thyroid gland: 17 nTPM

Single-cell type

early spermatids: 122 nCPM
late spermatids: 117 nCPM
enterocytes: 71 nCPM
colonocytes: 60 nCPM
t-cells: 55 nCPM
granulosa cells: 51 nCPM

Immune cell

NK-cell: 4.2 nTPM
gdT-cell: 3.3 nTPM
eosinophil: 2.4 nTPM
intermediate monocyte: 2.2 nTPM
memory CD8 T-cell: 2.2 nTPM
total PBMC: 2 nTPM

Brain region

cerebellum: 27 nTPM
cerebral cortex: 23 nTPM
hippocampal formation: 20 nTPM
white matter: 20 nTPM
amygdala: 19 nTPM
basal ganglia: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF335.

Disease | AllUniProt

Conditions ZNF335 is implicated in, by any mechanism.

Microcephaly 10, primary, autosomal recessive (MCPH10) MIM:615095

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 758 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephalic primordial dwarfism due to ZNF335 deficiency
Inborn genetic diseases
ZNF335-related disorder
Fetal anomalies with a likely genetic cause

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.72
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF335 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF335 as an antibody target. Whether an autoantibody or antibody against ZNF335 could matter depends on whether native ZNF335 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF335 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF335 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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