Seroatlas · Human Serome Atlas

KANSL2

KAT8 regulatory NSL complex subunit 2

Also known as: C12orf41, FLJ20436, KANL2_HUMAN, NSL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H9L4
Gene
KANSL2
Ensembl
ENSG00000139620
Chromosome
12
Canonical length
492 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to be involved in positive regulation of DNA-templated transcription. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of NSL complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q9H9L4|KANSL2
     1  MNRIRIHVLP TNRGRITPVP RSQEPLSCAF THRPCSHPRL EGQEFCIKHI LEDKNAPFKQ
    61  CSYISTKNGK RCPNAAPKPE KKDGVSFCAE HVRRNALALH AQMKKTNPGP VGETLLCQLS
   121  SYAKTELGSQ TPESSRSEAS RILDEDSWSD GEQEPITVDQ TWRGDPDSEA DSIDSDQEDP
   181  LKHAGVYTAE EVALIMREKL IRLQSLYIDQ FKRLQHLLKE KKRRYLHNRK VEHEALGSSL
   241  LTGPEGLLAK ERENLKRLKC LRRYRQRYGV EALLHRQLKE RRMLATDGAA QQAHTTRSSQ
   301  RCLAFVDDVR CSNQSLPMTR HCLTHICQDT NQVLFKCCQG SEEVPCNKPV PVSLSEDPCC
   361  PLHFQLPPQM YKPEQVLSVP DDLEAGPMDL YLSAAELQPT ESLPLEFSDD LDVVGDGMQC
   421  PPSPLLFDPS LTLEDHLVKE IAEDPVDILG QMQMAGDGCR SQGSRNSEKA SAPLSQSGLA
   481  TANGKPEPTS IS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KANSL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 40 nTPM
  • skeletal muscle: 34 nTPM
  • tongue: 22 nTPM
  • cerebellum: 13 nTPM
  • thymus: 13 nTPM
  • lymph node: 13 nTPM

Single-cell type

  • neutrophil progenitors: 70 nCPM
  • myonuclei: 67 nCPM
  • innate lymphoid cells: 65 nCPM
  • early primary spermatocytes: 60 nCPM
  • nk-cells: 54 nCPM
  • t-cells: 52 nCPM

Immune cell

  • basophil: 36 nTPM
  • T-reg: 32 nTPM
  • naive CD4 T-cell: 28 nTPM
  • memory B-cell: 28 nTPM
  • naive CD8 T-cell: 27 nTPM
  • memory CD8 T-cell: 26 nTPM

Brain region

  • cerebellum: 14 nTPM
  • white matter: 14 nTPM
  • choroid plexus: 11 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 11 nTPM
  • basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.88
gnomAD missense Z
1.49
DepMap mean gene effect
-1.1
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KANSL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KANSL2 as an antibody target. Whether an autoantibody or antibody against KANSL2 could matter depends on whether native KANSL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KANSL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KANSL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KANSL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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