Seroatlas · Human Serome Atlas

RIPK1

Receptor-interacting serine/threonine-protein kinase 1

Also known as: RIP, RIP-1, RIP1, RIPK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13546
Gene
RIPK1
Ensembl
ENSG00000137275
Chromosome
6
Canonical length
671 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

671 residues, UniProt reviewed canonical sequence.

>Q13546|RIPK1
     1  MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG PNCIEHNEAL
    61  LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL MHVLKAEMST PLSVKGRIIL
   121  EIIEGMCYLH GKGVIHKDLK PENILVDNDF HIKIADLGLA SFKMWSKLNN EEHNELREVD
   181  GTAKKNGGTL YYMAPEHLND VNAKPTEKSD VYSFAVVLWA IFANKEPYEN AICEQQLIMC
   241  IKSGNRPDVD DITEYCPREI ISLMKLCWEA NPEARPTFPG IEEKFRPFYL SQLEESVEED
   301  VKSLKKEYSN ENAVVKRMQS LQLDCVAVPS SRSNSATEQP GSLHSSQGLG MGPVEESWFA
   361  PSLEHPQEEN EPSLQSKLQD EANYHLYGSR MDRQTKQQPR QNVAYNREEE RRRRVSHDPF
   421  AQQRPYENFQ NTEGKGTAYS SAASHGNAVH QPSGLTSQPQ VLYQNNGLYS SHGFGTRPLD
   481  PGTAGPRVWY RPIPSHMPSL HNIPVPETNY LGNTPTMPFS SLPPTDESIK YTIYNSTGIQ
   541  IGAYNYMEIG GTSSSLLDST NTNFKEEPAA KYQAIFDNTT SLTDKHLDPI RENLGKHWKN
   601  CARKLGFTQS QIDEIDHDYE RDGLKEKVYQ MLQKWVMREG IKGATVGKLA QALHQCSRID
   661  LLSSLIYVSQ N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIPK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • liver: 17 nTPM
  • urinary bladder: 13 nTPM
  • small intestine: 13 nTPM
  • rectum: 12 nTPM
  • tonsil: 12 nTPM
  • colon: 12 nTPM

Single-cell type

  • enterocytes: 345 nCPM
  • colonocytes: 310 nCPM
  • rod photoreceptor cells: 247 nCPM
  • neutrophils: 225 nCPM
  • goblet cells: 186 nCPM
  • breast myoepithelial cells: 149 nCPM

Immune cell

  • memory CD8 T-cell: 1.7 nTPM
  • T-reg: 1.7 nTPM
  • NK-cell: 1.5 nTPM
  • naive B-cell: 1.3 nTPM
  • MAIT T-cell: 1 nTPM
  • myeloid DC: 1 nTPM

Brain region

  • choroid plexus: 2.4 nTPM
  • medulla oblongata: 2.1 nTPM
  • pons: 1.6 nTPM
  • thalamus: 1.6 nTPM
  • spinal cord: 1.5 nTPM
  • basal ganglia: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RIPK1.

Disease | AllUniProt

Conditions RIPK1 is implicated in, by any mechanism.

  • Immunodeficiency 57 with autoinflammation (IMD57) MIM:618108
  • Autoinflammation with episodic fever and lymphadenopathy (AIEFL) MIM:618852

Disease | GeneticClinVar

25 pathogenic / likely-pathogenic of 580 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on RIPK1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.01
gnomAD missense Z
1.56
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIPK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIPK1 as an antibody target. Whether an autoantibody or antibody against RIPK1 could matter depends on whether native RIPK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIPK1 is annotated at the cell surface, where native RIPK1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RIPK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIPK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...