Seroatlas · Human Serome Atlas

ANXA1

Annexin A1

Also known as: ANX1, ANXA1_HUMAN, LPC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04083
Gene
ANXA1
Ensembl
ENSG00000135046
Chromosome
9
Canonical length
346 aa
Protein class
Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>P04083|ANXA1
     1  MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV
    61  DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL TGHLEEVVLA LLKTPAQFDA
   121  DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL
   181  LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY
   241  TKYSKHDMNK VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM
   301  VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
7,699 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 7,699 nTPM
  • bone marrow: 2,012 nTPM
  • vagina: 1,680 nTPM
  • salivary gland: 1,501 nTPM
  • tonsil: 1,393 nTPM
  • cervix: 1,390 nTPM

Single-cell type

  • esophageal apical cells: 89,659 nCPM
  • esophageal suprabasal cells: 19,784 nCPM
  • syncytiotrophoblasts: 10,181 nCPM
  • ocular epithelial cells: 7,882 nCPM
  • suprabasal keratinocytes: 6,802 nCPM
  • epididymal basal cells: 5,147 nCPM

Immune cell

  • basophil: 2,824 nTPM
  • eosinophil: 2,233 nTPM
  • total PBMC: 2,021 nTPM
  • myeloid DC: 1,515 nTPM
  • classical monocyte: 1,239 nTPM
  • MAIT T-cell: 758 nTPM

Brain region

  • medulla oblongata: 76 nTPM
  • hypothalamus: 76 nTPM
  • midbrain: 59 nTPM
  • thalamus: 58 nTPM
  • white matter: 48 nTPM
  • spinal cord: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANXA1.

Disease | ImmuneIEDB

Conditions an epitope on ANXA1 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against ANXA1 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for ANXA1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

22 publications

Show 17 more

Reference: B cellIEDB

1 publication

Reference: T cellIEDB

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
0.05
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANXA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANXA1 as an antibody target. Whether an autoantibody or antibody against ANXA1 could matter depends on whether native ANXA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANXA1 is annotated at the cell surface, where native ANXA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANXA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANXA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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