Seroatlas · Human Serome Atlas

PGAM5

Serine/threonine-protein phosphatase PGAM5, mitochondrial

Also known as: BXLBv68, MGC5352, PGAM5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HS1
Gene
PGAM5
Ensembl
ENSG00000247077
Chromosome
12
Canonical length
289 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Mitochondria
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Enables GTPase activator activity and protein serine/threonine phosphatase activity. Involved in necroptotic process. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q96HS1|PGAM5
     1  MAFRQALQLA ACGLAGGSAA VLFSAVAVGK PRAGGDAEPR PAEPPAWAGG ARPGPGVWDP
    61  NWDRREPLSL INVRKRNVES GEEELASKLD HYKAKATRHI FLIRHSQYHV DGSLEKDRTL
   121  TPLGREQAEL TGLRLASLGL KFNKIVHSSM TRAIETTDII SRHLPGVCKV STDLLREGAP
   181  IEPDPPVSHW KPEAVQYYED GARIEAAFRN YIHRADARQE EDSYEIFICH ANVIRYIVCR
   241  ALQFPPEGWL RLSLNNGSIT HLVIRPNGRV ALRTLGDTGF MPPDKITRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGAM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 31 nTPM
  • liver: 27 nTPM
  • pancreas: 24 nTPM
  • esophagus: 22 nTPM
  • lymph node: 20 nTPM
  • heart muscle: 19 nTPM

Single-cell type

  • late spermatids: 32 nCPM
  • epicardial cells: 30 nCPM
  • hepatocytes: 25 nCPM
  • esophageal basal cells: 24 nCPM
  • adrenal medulla cells: 21 nCPM
  • late primary spermatocytes: 21 nCPM

Immune cell

  • basophil: 4.7 nTPM
  • plasmacytoid DC: 3.4 nTPM
  • MAIT T-cell: 1.8 nTPM
  • memory B-cell: 1.7 nTPM
  • NK-cell: 1.7 nTPM
  • non-classical monocyte: 1.7 nTPM

Brain region

  • hippocampal formation: 54 nTPM
  • cerebral cortex: 50 nTPM
  • basal ganglia: 41 nTPM
  • hypothalamus: 41 nTPM
  • cerebellum: 39 nTPM
  • white matter: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.96
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PGAM5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGAM5 as an antibody target. Whether an autoantibody or antibody against PGAM5 could matter depends on whether native PGAM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGAM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGAM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PGAM5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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