Seroatlas · Human Serome Atlas

TRADD

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Also known as: Hs.89862, TRADD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15628
Gene
TRADD
Ensembl
ENSG00000102871
Chromosome
16
Canonical length
312 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q15628|TRADD
     1  MAAGQNGHEE WVGSAYLFVE SSLDKVVLSD AYAHPQQKVA VYRALQAALA ESGGSPDVLQ
    61  MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ RSLAAALAQH SVPLQLELRA
   121  GAERLDALLA DEERCLSCIL AQQPDRLRDE ELAELEDALR NLKCGSGARG GDGEVASAPL
   181  QPPVPSLSEV KPPPPPPPAQ TFLFQGQPVV NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG
   241  CRALRDPALD SLAYEYEREG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED
   301  LLGLTDPNGG LA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRADD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 34 nTPM
  • esophagus: 32 nTPM
  • salivary gland: 27 nTPM
  • skin: 26 nTPM
  • kidney: 25 nTPM
  • prostate: 24 nTPM

Single-cell type

  • esophageal apical cells: 141 nCPM
  • esophageal suprabasal cells: 125 nCPM
  • esophageal basal cells: 75 nCPM
  • fallopian tube ciliated cells: 71 nCPM
  • plasma cells: 70 nCPM
  • extravillous trophoblasts: 60 nCPM

Immune cell

  • memory CD4 T-cell: 166 nTPM
  • memory CD8 T-cell: 96 nTPM
  • eosinophil: 95 nTPM
  • MAIT T-cell: 84 nTPM
  • T-reg: 82 nTPM
  • non-classical monocyte: 79 nTPM

Brain region

  • medulla oblongata: 16 nTPM
  • pons: 14 nTPM
  • white matter: 13 nTPM
  • spinal cord: 13 nTPM
  • cerebellum: 11 nTPM
  • choroid plexus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.1
gnomAD missense Z
1.51
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRADD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRADD as an antibody target. Whether an autoantibody or antibody against TRADD could matter depends on whether native TRADD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRADD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRADD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRADD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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