Seroatlas · Human Serome Atlas

RNF34

E3 ubiquitin-protein ligase RNF34

Also known as: FLJ21786, RIF, RIFF, RNF34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969K3
Gene
RNF34
Ensembl
ENSG00000170633
Chromosome
12
Canonical length
372 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q969K3|RNF34
     1  MKAGATSMWA SCCGLLNEVM GTGAVRGQQS AFAGATGPFR FTPNPEFSTY PPAATEGPNI
    61  VCKACGLSFS VFRKKHVCCD CKKDFCSVCS VLQENLRRCS TCHLLQETAF QRPQLMRLKV
   121  KDLRQYLILR NIPIDTCREK EDLVDLVLCH HGLGSEDDMD TSSLNSSRSQ TSSFFTRSFF
   181  SNYTAPSATM SSFQGELMDG DQTSRSGVPA QVQSEITSAN TEDDDDDDDE DDDDEEENAE
   241  DRNPGLSKER VRASLSDLSS LDDVEGMSVR QLKEILARNF VNYSGCCEKW ELVEKVNRLY
   301  KENEENQKSY GERLQLQDEE DDSLCRICMD AVIDCVLLEC GHMVTCTKCG KRMSECPICR
   361  QYVVRAVHVF KS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 56 nTPM
  • tongue: 35 nTPM
  • lymph node: 33 nTPM
  • thymus: 26 nTPM
  • tonsil: 26 nTPM
  • cerebellum: 25 nTPM

Single-cell type

  • early primary spermatocytes: 258 nCPM
  • myonuclei: 197 nCPM
  • oocytes: 134 nCPM
  • enterocytes: 126 nCPM
  • epididymal clear cells: 114 nCPM
  • cholangiocytes: 107 nCPM

Immune cell

  • T-reg: 109 nTPM
  • eosinophil: 94 nTPM
  • basophil: 87 nTPM
  • memory CD4 T-cell: 86 nTPM
  • memory B-cell: 79 nTPM
  • NK-cell: 79 nTPM

Brain region

  • white matter: 56 nTPM
  • cerebellum: 56 nTPM
  • basal ganglia: 51 nTPM
  • cerebral cortex: 50 nTPM
  • hypothalamus: 49 nTPM
  • midbrain: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.61
gnomAD missense Z
1.44
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF34 as an antibody target. Whether an autoantibody or antibody against RNF34 could matter depends on whether native RNF34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF34 is annotated at the cell surface, where native RNF34 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RNF34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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