Seroatlas · Human Serome Atlas

FADD

FAS-associated death domain protein

Also known as: FADD_HUMAN, GIG3, MORT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13158
Gene
FADD
Ensembl
ENSG00000168040
Chromosome
11
Canonical length
208 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q13158|FADD
     1  MDPFLVLLHS VSSSLSSSEL TELKFLCLGR VGKRKLERVQ SGLDLFSMLL EQNDLEPGHT
    61  ELLRELLASL RRHDLLRRVD DFEAGAAAGA APGEEDLCAA FNVICDNVGK DWRRLARQLK
   121  VSDTKIDSIE DRYPRNLTER VRESLRIWKN TEKENATVAH LVGALRSCQM NLVADLVQEV
   181  QQARDLQNRS GAMSPMSWNS DASTSEAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FADD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 19 nTPM
  • epididymis: 17 nTPM
  • lymph node: 16 nTPM
  • tonsil: 16 nTPM
  • esophagus: 15 nTPM
  • liver: 15 nTPM

Single-cell type

  • cytotrophoblasts: 93 nCPM
  • migrating cytotrophoblasts: 62 nCPM
  • esophageal basal cells: 51 nCPM
  • esophageal suprabasal cells: 43 nCPM
  • extravillous trophoblasts: 43 nCPM
  • hofbauer cells: 31 nCPM

Immune cell

  • neutrophil: 89 nTPM
  • memory CD8 T-cell: 49 nTPM
  • MAIT T-cell: 48 nTPM
  • T-reg: 46 nTPM
  • non-classical monocyte: 46 nTPM
  • naive CD4 T-cell: 45 nTPM

Brain region

  • medulla oblongata: 15 nTPM
  • pons: 13 nTPM
  • thalamus: 13 nTPM
  • spinal cord: 13 nTPM
  • white matter: 12 nTPM
  • midbrain: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FADD.

Disease | AllUniProt

Conditions FADD is implicated in, by any mechanism.

  • Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations (IEHDCM) MIM:613759

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 155 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • FADD-related immunodeficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0.53
gnomAD missense Z
0.84
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FADD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FADD as an antibody target. Whether an autoantibody or antibody against FADD could matter depends on whether native FADD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FADD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FADD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FADD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...