Seroatlas · Human Serome Atlas

PELI1

E3 ubiquitin-protein ligase pellino homolog 1

Also known as: PELI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FA3
Gene
PELI1
Ensembl
ENSG00000197329
Chromosome
2
Canonical length
418 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Intermediate filaments,Centriolar satellite,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Enables ubiquitin-ubiquitin ligase activity. Involved in several processes, including negative regulation of TORC1 signaling; negative regulation of necroptotic process; and protein polyubiquitination. Is active in site of double-strand break. Implicated in colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q96FA3|PELI1
     1  MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA
    61  CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG
   121  SQSNSDTQSV QSTISRFACR IICERNPPFT ARIYAAGFDS SKNIFLGEKA AKWKTSDGQM
   181  DGLTTNGVLV MHPRNGFTED SKPGIWREIS VCGNVFSLRE TRSAQQRGKM VEIETNQLQD
   241  GSLIDLCGAT LLWRTAEGLS HTPTVKHLEA LRQEINAARP QCPVGFNTLA FPSMKRKDVV
   301  DEKQPWVYLN CGHVHGYHNW GNKEERDGKD RECPMCRSVG PYVPLWLGCE AGFYVDAGPP
   361  THAFSPCGHV CSEKTTAYWS QIPLPHGTHT FHAACPFCAH QLAGEQGYIR LIFQGPLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PELI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
216 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 216 nTPM
  • esophagus: 40 nTPM
  • parathyroid gland: 36 nTPM
  • lung: 30 nTPM
  • skin: 29 nTPM
  • tonsil: 27 nTPM

Single-cell type

  • neutrophils: 4,332 nCPM
  • plasma cells: 1,723 nCPM
  • esophageal apical cells: 1,055 nCPM
  • alveolar cells type 2: 1,029 nCPM
  • transitional alveolar cells: 913 nCPM
  • monocytes: 871 nCPM

Immune cell

  • neutrophil: 77 nTPM
  • non-classical monocyte: 23 nTPM
  • classical monocyte: 16 nTPM
  • basophil: 15 nTPM
  • eosinophil: 15 nTPM
  • intermediate monocyte: 14 nTPM

Brain region

  • white matter: 23 nTPM
  • basal ganglia: 22 nTPM
  • hippocampal formation: 20 nTPM
  • spinal cord: 18 nTPM
  • medulla oblongata: 17 nTPM
  • cerebellum: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.39
gnomAD missense Z
2.12
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PELI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PELI1 as an antibody target. Whether an autoantibody or antibody against PELI1 could matter depends on whether native PELI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PELI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PELI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PELI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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