Rel homology domain (RHD), DNA-binding domain superfamily

Definition

The Rel homology domain (RHD) is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish, NFAT, among others. The RHD is composed of two structural domains: the N-terminal DNA binding domain that is similar to that found in P53, the C-terminal domain has an immunoglobulin-like fold (See [pfam:PF16179]) that functions as a dimerisation domain. This entry represents the N-terminal DNA binding domain superfamily PMID:17869269.

10 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (10 proteins: gene, accession, name)

• NFAT5
• NFATC1
• NFATC2
• NFATC3
• NFATC4
• NFKB1
• NFKB2
• REL
• RELA
• RELB