Rel homology domain, conserved site

Definition

Members of the Rel family share a highly conserved 300 amino acids domain termed Rel homology domain (RHD) which is located towards the amino terminus. The unique C terminus is thought to be involved in gene activation and cytoplasmic anchoring functions. For several proteins it has been demonstrated PMID:8061327 that the Rel homology domain includes: a DNA-binding domain, which binds to the consensus DNA sequence motif 5'-GGGRNNYYCC-3' (except for dorsal, which recognises the related motif 5'-GRGAAAANCC-3'); a dimerisation domain, which is located in the C-terminal part of the RHD; a PKA phosphorylation site (except in RelB); a nuclear localization signal (NLS), which consists of a stretch of four or five basic residues. This entry represents a conserved site located at the N terminus of the RHD. It includes a conserved cysteine that seems to be essential for DNA-binding in p50 PMID:8056331.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• NFKB1
• NFKB2
• REL
• RELA
• RELB