Seroatlas · Human Serome Atlas

NFKBID

NF-kappa-B inhibitor delta

Also known as: IkappaBNS, IKBD_HUMAN, IkBNS, TA-NFKBH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NI38
Gene: NFKBID
Ensembl: ENSG00000167604
Chromosome: 19
Canonical length: 313 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable NF-kappaB binding activity. Predicted to be involved in T cell receptor signaling pathway; positive regulation of T-helper 17 cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of thymocyte apoptotic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NI38|NFKBID
     1  MEAGPWRVSA PPSGPPQFPA VVPGPSLEVA RAHMLALGPQ QLLAQDEEGD TLLHLFAARG
    61  LRWAAYAAAE VLQVYRRLDI REHKGKTPLL VAAAANQPLI VEDLLNLGAE PNAADHQGRS
   121  VLHVAATYGL PGVLLAVLNS GVQVDLEARD FEGLTPLHTA ILALNVAMRP SDLCPRVLST
   181  QARDRLDCVH MLLQMGANHT SQEIKSNKTV LHLAVQAANP TLVQLLLELP RGDLRTFVNM
   241  KAHGNTALHM AAALPPGPAQ EAIVRHLLAA GADPTLRNLE NEQPVHLLRP GPGPEGLRQL
   301  LKRSRVAPPG LSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFKBID can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 19 nTPM
thymus: 6.9 nTPM
lymph node: 6.2 nTPM
appendix: 5.7 nTPM
lung: 5.3 nTPM
spleen: 5.1 nTPM

Single-cell type

neutrophils: 490 nCPM
cdc: 287 nCPM
mast cells: 204 nCPM
monocytes: 192 nCPM
neutrophil progenitors: 155 nCPM
pdcs: 148 nCPM

Immune cell

naive B-cell: 7.3 nTPM
memory B-cell: 5 nTPM
neutrophil: 3.9 nTPM
eosinophil: 2.3 nTPM
plasmacytoid DC: 2 nTPM
gdT-cell: 1.9 nTPM

Brain region

cerebellum: 7 nTPM
choroid plexus: 5.7 nTPM
white matter: 4.9 nTPM
cerebral cortex: 4.4 nTPM
hypothalamus: 4.4 nTPM
medulla oblongata: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.32
gnomAD missense Z: 2.03
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFKBID in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFKBID as an antibody target. Whether an autoantibody or antibody against NFKBID could matter depends on whether native NFKBID is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFKBID is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFKBID as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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