Rel homology domain, DNA-binding domain

Definition

The Rel homology domain (RHD) is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish, NFAT, among others. The RHD is composed of two structural domains that grip the DNA in the major groove: the N-terminal DNA binding domain and the C-terminal domain, which has an immunoglobulin-like fold (See [pfam:PF16179]). This entry represents the N-terminal DNA binding domain, whose specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases. The C-terminal dimerisation domain contains the site for interaction with I-kappaB [[cite:PMID:7830764], [cite:PMID:17869269]].

10 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (10 proteins: gene, accession, name)

• NFAT5
• NFATC1
• NFATC2
• NFATC3
• NFATC4
• NFKB1
• NFKB2
• REL
• RELA
• RELB