Seroatlas · Human Serome Atlas

ARMC12

Armadillo repeat-containing protein 12

Also known as: ARM12_HUMAN, C6orf81, FLJ25390

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T9G4
Gene
ARMC12
Ensembl
ENSG00000157343
Chromosome
6
Canonical length
340 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Involved in positive regulation of cell growth and sperm mitochondrial sheath assembly. Located in nucleus. Implicated in spermatogenic failure 90. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q5T9G4|ARMC12
     1  MGKSIPQYLG QLDIRKSVVS LATGAGAIYL LYKAIKAGIK CKPPLCSNSP ICIARLAVER
    61  ERHGRDSGEL RRLLNSLECK QDEYAKSMIL HSITRCVYLL EAEASACTTD DIVLLGYMLD
   121  DKDNSVKTQA LNTLKAFSGI RKFRLKIQEH SIKVLELIST IWDTELHIAG LRLLNNLPLP
   181  DYVHPQLRRV MPALMEILQS DYILAQVQAV RLLSYLAQKN DLLYDILNCQ VHSNFLNLFQ
   241  PTQSGSLLYE VLVFAERLSE GRNAPHYHVV KWHYNEQSLH ESLFGEESRL ADRLLALVIH
   301  PEEDVQIQAC KVIVSLQYPQ DLRARPSSCQ PSRSYFKNTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • testis: 58 nTPM
  • pituitary gland: 11 nTPM
  • epididymis: 5.5 nTPM
  • choroid plexus: 5.3 nTPM
  • liver: 4.3 nTPM
  • basal ganglia: 3.4 nTPM

Single-cell type

  • late spermatids: 1,623 nCPM
  • early spermatids: 501 nCPM
  • late primary spermatocytes: 246 nCPM
  • undifferentiated spermatogonia: 5.9 nCPM
  • hepatocytes: 4.3 nCPM
  • neutrophils: 4.2 nCPM

Immune cell

  • naive CD8 T-cell: 0.9 nTPM
  • plasmacytoid DC: 0.8 nTPM
  • classical monocyte: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • myeloid DC: 0.2 nTPM

Brain region

  • midbrain: 3.8 nTPM
  • choroid plexus: 3.7 nTPM
  • cerebral cortex: 3.1 nTPM
  • medulla oblongata: 2.7 nTPM
  • hypothalamus: 2.5 nTPM
  • white matter: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARMC12.

Disease | AllUniProt

Conditions ARMC12 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 64 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 90

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.27
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMC12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMC12 as an antibody target. Whether an autoantibody or antibody against ARMC12 could matter depends on whether native ARMC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARMC12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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