Seroatlas · Human Serome Atlas

ZNF827

Zinc finger protein 827

Also known as: ZN827_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17R98
Gene: ZNF827
Ensembl: ENSG00000151612
Chromosome: 4
Canonical length: 1081 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables NuRD complex binding activity. Involved in several processes, including establishment of protein localization to telomere; negative regulation of shelterin complex assembly; and telomere maintenance. Located in chromatin and chromosome, telomeric region. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1081 residues, UniProt reviewed canonical sequence.

>Q17R98|ZNF827
     1  MPRRKQEQPK RLPSHVSRQE EAEGELSEGE HWYGNSSETP SEASYGEVQE NYKLSLEDRI
    61  QEQSTSPDTS LGSTTPSSHT LELVALDSEV LRDSLQCQDH LSPGVSSLCD DDPGSNKPLS
   121  SNLRRLLEAG SLKLDAAATA NGRVESPVNV GSNLSFSPPS HHAQQLSVLA RKLAEKQEQN
   181  DQYTPSNRFI WNQGKWLPNS TTTCSLSPDS AILKLKAAAN AVLQDKSLTR TEETMRFESF
   241  SSPFSSQSAS STLAALSKKV SERSLTPGQE HPPPASSFLS LASMTSSAAL LKEVAARAAG
   301  SLLAEKSSLL PEDPLPPPPS EKKPEKVTPP PPPPPPPPPP PPPQSLELLL LPVPKGRVSK
   361  PSNSASEEES GKPFQCPICG LVIKRKSYWK RHMVIHTGLK SHQCPLCPFR CARKDNLKSH
   421  MKVHQHQDRG ETFQCQLCPF TSSRHFSLKL HMRCHQHFLR TEAKVKEEIP DPDVKGSPHL
   481  SDSACLGQQR EGGGTELVGT MMTSNTPERT SQGGAGVSPL LVKEEPKEDN GLPTSFTLNA
   541  ADRPANHTKL KDPSEYVANS ASALFSQDIS VKMASDFLMK LSAANQKEPM NLNFKVKEEP
   601  KEGESLSTTL PRSSYVFSPE SEVSAPGVSE DALKPQEGKG SVLRRDVSVK AASELLMKLS
   661  AESYKETQMV KIKEEPMEVD IQDSHVSISP SRNVGYSTLI GREKTEPLQK MPEGRVPPER
   721  NLFSQDISVK MASELLFQLS EKVSKEHNHT KENTIRTTTS PFFSEDTFRQ SPFTSNSKEL
   781  LPSDSVLHGR ISAPETEKIV LEAGNGLPSW KFNDQLFPCD VCGKVFGRQQ TLSRHLSLHT
   841  EERKYKCHLC PYAAKCRANL NQHLTVHSVK LVSTDTEDIV SAVTSEGSDG KKHPYYYSCH
   901  VCGFETELNV QFVSHMSLHV DKEQWMFSIC CTACDFVTME EAEIKTHIGT KHTGEDRKTP
   961  SESNSPSSSS LSALSDSANS KDDSDGSQKN KGGNNLLVIS VMPGSQPSLN SEEKPEKGFE
  1021  CVFCNFVCKT KNMFERHLQI HLITRMFECD VCHKFMKTPE QLLEHKKCHT VPTGGLNSGQ
  1081  W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF827 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

prostate: 15 nTPM
salivary gland: 10 nTPM
thymus: 6.8 nTPM
parathyroid gland: 6.6 nTPM
small intestine: 6.1 nTPM
cerebral cortex: 5.9 nTPM

Single-cell type

prostatic glandular cells: 1,374 nCPM
salivary acinar cells: 339 nCPM
thymocytes: 281 nCPM
thyrotrophs: 267 nCPM
somatotrophs: 267 nCPM
oligodendrocyte progenitor cells: 256 nCPM

Immune cell

basophil: 2.9 nTPM
NK-cell: 2 nTPM
gdT-cell: 1.8 nTPM
memory CD8 T-cell: 1.8 nTPM
memory B-cell: 1.7 nTPM
naive CD8 T-cell: 1.7 nTPM

Brain region

cerebellum: 34 nTPM
basal ganglia: 27 nTPM
cerebral cortex: 25 nTPM
white matter: 23 nTPM
medulla oblongata: 20 nTPM
hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 1.9
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin remodeling
establishment of protein localization to telomere
negative regulation of DNA-templated transcription
positive regulation of transcription by RNA polymerase II
telomere maintenance
negative regulation of shelterin complex assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF827 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF827 as an antibody target. Whether an autoantibody or antibody against ZNF827 could matter depends on whether native ZNF827 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF827 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF827 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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