Seroatlas · Human Serome Atlas

AEBP2

Zinc finger protein AEBP2

Also known as: AEBP2_HUMAN, MGC17922

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZN18
Gene
AEBP2
Ensembl
ENSG00000139154
Chromosome
12
Canonical length
517 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity; transcription coregulator activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Located in nucleoplasm. Part of ESC/E(Z) complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q6ZN18|AEBP2
     1  MAAAITDMAD LEELSRLSPL PPGSPGSAAR GRAEPPEEEE EEEEEEEEAE AEAVAALLLN
    61  GGSGGGGGGG GGGVGGGEAE TMSEPSPESA SQAGEDEDEE EDDEEEEDES SSSGGGEEES
   121  SAESLVGSSG GSSSDETRSL SPGAASSSSG DGDGKEGLEE PKGPRGSQGG GGGGSSSSSV
   181  VSSGGDEGYG TGGGGSSATS GGRRGSLEMS SDGEPLSRMD SEDSISSTIM DVDSTISSGR
   241  STPAMMNGQG STTSSSKNIA YNCCWDQCQA CFNSSPDLAD HIRSIHVDGQ RGGVFVCLWK
   301  GCKVYNTPST SQSWLQRHML THSGDKPFKC VVGGCNASFA SQGGLARHVP THFSQQNSSK
   361  VSSQPKAKEE SPSKAGMNKR RKLKNKRRRS LPRPHDFFDA QTLDAIRHRA ICFNLSAHIE
   421  SLGKGHSVVF HSTVIAKRKE DSGKIKLLLH WMPEDILPDV WVNESERHQL KTKVVHLSKL
   481  PKDTALLLDP NIYRTMPQKR LKRTLIRKVF NLYLSKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AEBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 41 nTPM
  • blood vessel: 37 nTPM
  • esophagus: 33 nTPM
  • endometrium: 32 nTPM
  • ovary: 31 nTPM
  • tonsil: 30 nTPM

Single-cell type

  • choroid plexus epithelial cells: 455 nCPM
  • brain excitatory neurons: 387 nCPM
  • retinal ganglion cells: 375 nCPM
  • ependymal cells: 373 nCPM
  • other brain neurons: 347 nCPM
  • distal convoluted tubule cells: 335 nCPM

Immune cell

  • NK-cell: 6 nTPM
  • naive CD8 T-cell: 5.8 nTPM
  • T-reg: 4.5 nTPM
  • MAIT T-cell: 4.4 nTPM
  • memory CD4 T-cell: 4.4 nTPM
  • basophil: 4.3 nTPM

Brain region

  • hippocampal formation: 118 nTPM
  • cerebral cortex: 116 nTPM
  • white matter: 110 nTPM
  • hypothalamus: 105 nTPM
  • choroid plexus: 103 nTPM
  • cerebellum: 103 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AEBP2.

Disease | ImmuneIEDB

Conditions an epitope on AEBP2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
2.21
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AEBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AEBP2 as an antibody target. Whether an autoantibody or antibody against AEBP2 could matter depends on whether native AEBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AEBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AEBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AEBP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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