Seroatlas · Human Serome Atlas

VDAC3

Non-selective voltage-gated ion channel VDAC3

Also known as: HD-VDAC3, VDAC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y277
Gene
VDAC3
Ensembl
ENSG00000078668
Chromosome
8
Canonical length
283 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q9Y277|VDAC3
     1  MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD TGKASGNLET
    61  KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD TIFVPNTGKK SGKLKASYKR
   121  DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL AGYQMSFDTA KSKLSQNNFA LGYKAADFQL
   181  HTHVNDGTEF GGSIYQKVNE KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA
   241  SLIGLGYTQT LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VDAC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
19
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
880 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 880 nTPM
  • skeletal muscle: 857 nTPM
  • heart muscle: 361 nTPM
  • cerebellum: 152 nTPM
  • cerebral cortex: 148 nTPM
  • hypothalamus: 131 nTPM

Single-cell type

  • platelets: 581 nCPM
  • late primary spermatocytes: 498 nCPM
  • megakaryocytes: 464 nCPM
  • myonuclei: 297 nCPM
  • early primary spermatocytes: 295 nCPM
  • esophageal apical cells: 286 nCPM

Immune cell

  • total PBMC: 360 nTPM
  • myeloid DC: 223 nTPM
  • T-reg: 203 nTPM
  • eosinophil: 184 nTPM
  • intermediate monocyte: 167 nTPM
  • classical monocyte: 166 nTPM

Brain region

  • pons: 140 nTPM
  • hypothalamus: 121 nTPM
  • cerebral cortex: 109 nTPM
  • medulla oblongata: 104 nTPM
  • midbrain: 98 nTPM
  • thalamus: 95 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
0.99
gnomAD missense Z
1.1
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VDAC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VDAC3 as an antibody target. Whether an autoantibody or antibody against VDAC3 could matter depends on whether native VDAC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VDAC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VDAC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VDAC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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