Seroatlas · Human Serome Atlas

FAM114A2

Protein FAM114A2

Also known as: 133K02, C5orf3, F1142_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRY5
Gene: FAM114A2
Ensembl: ENSG00000055147
Chromosome: 5
Canonical length: 505 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable purine nucleotide binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q9NRY5|FAM114A2
     1  MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR KRPETKPSSD
    61  LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV ATVGQGISNV IEKAETSLGI
   121  PGPSEISTEV KYVAGETNAK ENENSSPVAG AFGVFSTIST AVQSTGKSVI SGGLDALEFI
   181  GKKTMDVIAE GDPGFKRTKG LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL
   241  FDEFQGLSHL EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE
   301  EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE NEEGEKQSEA
   361  ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV LHGRKQEVTA IERSQTLSQM
   421  TIVLCKELSS LSKEFTTCLT TAGVKEMADV LNPLITAVFL EASNSASYIQ DAFQLLLPVL
   481  EISLIENKIE SHRHELQGQK PLLEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM114A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

testis: 35 nTPM
parathyroid gland: 21 nTPM
skeletal muscle: 19 nTPM
heart muscle: 18 nTPM
tonsil: 16 nTPM
epididymis: 16 nTPM

Single-cell type

early primary spermatocytes: 106 nCPM
late primary spermatocytes: 100 nCPM
early spermatids: 47 nCPM
differentiating spermatogonia: 41 nCPM
erythrocyte progenitors: 40 nCPM
pancreatic acinar cells: 38 nCPM

Immune cell

basophil: 38 nTPM
eosinophil: 36 nTPM
non-classical monocyte: 23 nTPM
intermediate monocyte: 18 nTPM
memory CD8 T-cell: 18 nTPM
naive B-cell: 18 nTPM

Brain region

thalamus: 23 nTPM
hypothalamus: 22 nTPM
choroid plexus: 21 nTPM
midbrain: 20 nTPM
pons: 20 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

purine nucleotide binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM114A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAB2A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM114A2 as an antibody target. Whether an autoantibody or antibody against FAM114A2 could matter depends on whether native FAM114A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM114A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM114A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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