TOMM5
Mitochondrial import receptor subunit TOM5 homolog
Also known as: bA613M10.3, C9orf105, Tom5, TOM5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N4H5
- Gene
- TOMM5
- Ensembl
- ENSG00000175768
- Chromosome
- 9
- Canonical length
- 51 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Mitochondria
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in protein insertion into mitochondrial outer membrane. Located in mitochondrion. Part of mitochondrial outer membrane translocase complex. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
51 residues, UniProt reviewed canonical sequence.
>Q8N4H5|TOMM5
1 MFRIEGLAPK LDPEEMKRKM REDVISSIRN FLIYVALLRV TPFILKKLDS ILocalizationUniProt · AlphaFold · HPA
Whether an antibody against TOMM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 135 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 135 nTPM
- kidney: 130 nTPM
- adrenal gland: 95 nTPM
- adipose tissue: 94 nTPM
- pancreas: 94 nTPM
- esophagus: 93 nTPM
Single-cell type
- late primary spermatocytes: 157 nCPM
- late spermatids: 123 nCPM
- early spermatids: 114 nCPM
- parietal cells: 81 nCPM
- gastric chief cells: 73 nCPM
- suprabasal keratinocytes: 67 nCPM
Immune cell
- memory B-cell: 311 nTPM
- total PBMC: 280 nTPM
- naive B-cell: 262 nTPM
- MAIT T-cell: 253 nTPM
- naive CD4 T-cell: 253 nTPM
- memory CD4 T-cell: 248 nTPM
Brain region
- pons: 52 nTPM
- hypothalamus: 48 nTPM
- midbrain: 44 nTPM
- spinal cord: 42 nTPM
- cerebral cortex: 41 nTPM
- basal ganglia: 40 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.38
- gnomAD pLI
- 0.5
- gnomAD missense Z
- 0.32
- DepMap mean gene effect
- -0.16
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- protein insertion into mitochondrial outer membrane
- protein targeting to mitochondrion
- protein transport
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Mitochondrial outer membrane translocase complex, subunit Tom5
- Mitochondrial import receptor subunit TOM5, metazoa
- Mitochondrial import receptor subunit or translocase
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TOMM5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TOMM5 as an antibody target. Whether an autoantibody or antibody against TOMM5 could matter depends on whether native TOMM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TOMM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TOMM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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