Seroatlas · Human Serome Atlas

GDI2

Rab GDP dissociation inhibitor beta

Also known as: GDIB_HUMAN, RABGDIB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50395
Gene
GDI2
Ensembl
ENSG00000057608
Chromosome
10
Canonical length
445 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>P50395|GDI2
     1  MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE DLYKRFKIPG
    61  SPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL DFKVTEGSFV YKGGKIYKVP
   121  STEAEALASS LMGLFEKRRF RKFLVYVANF DEKDPRTFEG IDPKKTTMRD VYKKFDLGQD
   181  VIDFTGHALA LYRTDDYLDQ PCYETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR
   241  LSAIYGGTYM LNKPIEEIIV QNGKVIGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
   301  ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI AIVSTTVETK
   361  EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI SRTYDATTHF ETTCDDIKNI
   421  YKRMTGSEFD FEEMKRKKND IYGED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GDI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
225 nTPM

Expression across tissuesHPA

Tissue

  • liver: 225 nTPM
  • tonsil: 224 nTPM
  • lymph node: 203 nTPM
  • duodenum: 165 nTPM
  • pancreas: 156 nTPM
  • rectum: 151 nTPM

Single-cell type

  • oocytes: 852 nCPM
  • esophageal apical cells: 505 nCPM
  • migrating cytotrophoblasts: 388 nCPM
  • kupffer cells: 381 nCPM
  • extravillous trophoblasts: 377 nCPM
  • decidual stromal cells: 367 nCPM

Immune cell

  • non-classical monocyte: 447 nTPM
  • total PBMC: 417 nTPM
  • intermediate monocyte: 348 nTPM
  • myeloid DC: 330 nTPM
  • classical monocyte: 281 nTPM
  • memory B-cell: 212 nTPM

Brain region

  • white matter: 157 nTPM
  • medulla oblongata: 139 nTPM
  • spinal cord: 126 nTPM
  • pons: 116 nTPM
  • cerebellum: 115 nTPM
  • hypothalamus: 105 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.85
gnomAD missense Z
1.72
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GDI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GDI2 as an antibody target. Whether an autoantibody or antibody against GDI2 could matter depends on whether native GDI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GDI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GDI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GDI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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