VDAC1

Protein identityUniProt · HPA

UniProt accession

P21796

Gene

VDAC1

Ensembl

ENSG00000213585

Chromosome

5

Canonical length

283 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Quaternary structure

Homotrimer

OverviewNCBI Gene

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>P21796|VDAC1
     1  MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE TTKVTGSLET
    61  KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD SSFSPNTGKK NAKIKTGYKR
   121  EHINLGCDMD FDIAGPSIRG ALVLGYEGWL AGYQMNFETA KSRVTQSNFA VGYKTDEFQL
   181  HTNVNDGTEF GGSIYQKVNK KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS
   241  SLIGLGYTQT LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VDAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

19

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

980 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for VDAC1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.31

gnomAD pLI

0.97

gnomAD missense Z

1.33

DepMap mean gene effect

-0.76

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• behavioral fear response
• calcium import into the mitochondrion
• epithelial cell differentiation
• learning
• lipid transport
• mitochondrial transmembrane transport
• monoatomic anion transport
• negative regulation of apoptotic process
• negative regulation of calcium import into the mitochondrion
• negative regulation of reactive oxygen species metabolic process
• neuron-neuron synaptic transmission
• positive regulation of apoptotic process
• positive regulation of mitophagy
• positive regulation of type 2 mitophagy
• pyruvate biosynthetic process
• regulation of autophagy of mitochondrion

Molecular functions

• ATP binding
• ceramide binding
• cholesterol binding
• identical protein binding
• oxysterol binding
• phosphatidylcholine binding
• porin activity
• protein kinase binding
• transmembrane transporter binding
• voltage-gated monoatomic anion channel activity
• voltage-gated monoatomic ion channel activity

Cellular components

• extracellular exosome
• membrane
• membrane raft
• mitochondrial membrane
• mitochondrial nucleoid
• mitochondrial outer membrane
• mitochondrial permeability transition pore complex
• mitochondrion
• nucleus
• plasma membrane
• pore complex
• synapse

Protein domainsUniProt · Pfam · InterPro

• Porin, eukaryotic type
• Porin domain superfamily
• Eukaryotic porin/Tom40
• Eukaryotic porin

KeywordsUniProt

• Acetylation
• Apoptosis
• ATP-binding
• Cell membrane
• Host-virus interaction
• Ion transport
• Isopeptide bond
• Lipid transport
• Lipid-binding
• Membrane
• Mitochondrion
• Mitochondrion outer membrane
• NAD
• Nucleotide-binding
• Phosphoprotein
• Porin
• Transmembrane
• Transmembrane beta strand
• Transport
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of VDAC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APP
• ATF2
• BAK1
• BCAP31
• BCL2L1
• HSPA9
• NIPSNAP2
• SLC25A30
• SPG7
• TMEM41B
• HK1
• CYB5R3
• DCD
• HK2
• RAB2A
• RAB7A
• TOMM20
• VDAC2
• VDAC3