Seroatlas · Human Serome Atlas

VDAC2

Non-selective voltage-gated ion channel VDAC2

Also known as: VDAC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P45880
Gene
VDAC2
Ensembl
ENSG00000165637
Chromosome
10
Canonical length
294 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>P45880|VDAC2
     1  MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV EFSTSGSSNT
    61  DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED QICQGLKLTF DTTFSPNTGK
   121  KSGKIKSSYK RECINLGCDV DFDFAGPAIH GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF
   181  AVGYRTGDFQ LHTNVNDGTE FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP
   241  TASISAKVNN SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VDAC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
19
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
528 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 528 nTPM
  • skeletal muscle: 516 nTPM
  • heart muscle: 396 nTPM
  • esophagus: 309 nTPM
  • vagina: 205 nTPM
  • colon: 196 nTPM

Single-cell type

  • esophageal apical cells: 1,709 nCPM
  • esophageal suprabasal cells: 772 nCPM
  • enterocytes: 537 nCPM
  • late primary spermatocytes: 520 nCPM
  • colonocytes: 501 nCPM
  • esophageal basal cells: 496 nCPM

Immune cell

  • non-classical monocyte: 234 nTPM
  • myeloid DC: 214 nTPM
  • total PBMC: 210 nTPM
  • intermediate monocyte: 186 nTPM
  • classical monocyte: 174 nTPM
  • T-reg: 171 nTPM

Brain region

  • choroid plexus: 131 nTPM
  • cerebellum: 127 nTPM
  • white matter: 116 nTPM
  • pons: 113 nTPM
  • hypothalamus: 112 nTPM
  • midbrain: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.63
gnomAD missense Z
1.14
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VDAC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VDAC2 as an antibody target. Whether an autoantibody or antibody against VDAC2 could matter depends on whether native VDAC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VDAC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VDAC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VDAC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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