Seroatlas · Human Serome Atlas

CLIC1

Chloride intracellular channel protein 1

Also known as: CLCNL1, CLIC1_HUMAN, G6, NCC27, p64CLCP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00299
Gene
CLIC1
Ensembl
ENSG00000213719
Chromosome
6
Canonical length
241 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>O00299|CLIC1
     1  MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP
    61  GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN
   121  SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL
   181  LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL
   241  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLIC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
385 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 385 nTPM
  • urinary bladder: 325 nTPM
  • blood vessel: 322 nTPM
  • spleen: 321 nTPM
  • lung: 319 nTPM
  • skin: 312 nTPM

Single-cell type

  • platelets: 314 nCPM
  • suprabasal keratinocytes: 201 nCPM
  • basal keratinocytes: 180 nCPM
  • megakaryocytes: 179 nCPM
  • cdc: 131 nCPM
  • gastric chief cells: 118 nCPM

Immune cell

  • neutrophil: 940 nTPM
  • total PBMC: 675 nTPM
  • classical monocyte: 484 nTPM
  • basophil: 441 nTPM
  • eosinophil: 422 nTPM
  • myeloid DC: 379 nTPM

Brain region

  • hypothalamus: 73 nTPM
  • thalamus: 57 nTPM
  • medulla oblongata: 52 nTPM
  • spinal cord: 44 nTPM
  • cerebral cortex: 43 nTPM
  • white matter: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0
gnomAD missense Z
1.43
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLIC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLIC1 as an antibody target. Whether an autoantibody or antibody against CLIC1 could matter depends on whether native CLIC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLIC1 is annotated at the cell surface, where native CLIC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLIC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLIC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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