Seroatlas · Human Serome Atlas

PRMT1

Protein arginine N-methyltransferase 1

Also known as: ANM1, ANM1_HUMAN, HCP1, HRMT1L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99873
Gene
PRMT1
Ensembl
ENSG00000126457
Chromosome
19
Canonical length
371 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homooctamer

OverviewNCBI Gene

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q99873|PRMT1
     1  MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF
    61  GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS
   121  SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA
   181  RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV
   241  DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG
   301  FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC
   361  ELSCSTDYRM R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRMT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
227 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 227 nTPM
  • tongue: 152 nTPM
  • heart muscle: 140 nTPM
  • ovary: 113 nTPM
  • endometrium: 109 nTPM
  • fallopian tube: 103 nTPM

Single-cell type

  • migrating cytotrophoblasts: 285 nCPM
  • esophageal basal cells: 279 nCPM
  • decidual stromal cells: 244 nCPM
  • syncytiotrophoblasts: 241 nCPM
  • cytotrophoblasts: 222 nCPM
  • fallopian secretory cells: 206 nCPM

Immune cell

  • memory B-cell: 200 nTPM
  • naive B-cell: 173 nTPM
  • NK-cell: 163 nTPM
  • plasmacytoid DC: 159 nTPM
  • total PBMC: 133 nTPM
  • myeloid DC: 132 nTPM

Brain region

  • hypothalamus: 77 nTPM
  • pons: 73 nTPM
  • cerebellum: 71 nTPM
  • white matter: 68 nTPM
  • medulla oblongata: 68 nTPM
  • spinal cord: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.15
gnomAD pLI
1
gnomAD missense Z
3.81
DepMap mean gene effect
-1.25
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRMT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRMT1 as an antibody target. Whether an autoantibody or antibody against PRMT1 could matter depends on whether native PRMT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRMT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRMT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRMT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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