FAM9A
Protein FAM9A
Also known as: FAM9A_HUMAN, TEX39A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IZU1
- Gene
- FAM9A
- Ensembl
- ENSG00000183304
- Chromosome
- X
- Canonical length
- 332 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mid piece
OverviewNCBI Gene
This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein may be a nuclear protein that is localized to the nucleolus, and has some similarity to a synaptonemal complex protein. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]
Canonical amino-acid sequenceUniProt
332 residues, UniProt reviewed canonical sequence.
>Q8IZU1|FAM9A
1 MEPVGRKRSR KAAKAQLEAQ VTAAQGATKE GSGIASNFPG QPTMEPVGRK RSRKAAKAQL
61 EAQVRAAPAK KHTGKDPVRD ECEERNPFTE TREEDVTDEH GEREPFAEKD EHTGIHTMKL
121 EHIAADIKKG LAAKREMIKI DKAAYRKTKN TIERALKKKQ LKRQKRDYRH TRKLLNVLKE
181 YIAEKQKDDE AEEAEAAAAA AEAAAAAEAA AAAAEVIVVE DEEEEEKEEE EEKEEEEEEG
241 EEEGGGEEGE EGGGGGEGEE TEEEEEEEEE EEEEEQIKAF QEKQKRWQQP TGVRSWRLRE
301 MKPLLEQLLK AAKDTKDNYC IISSSEESEL DNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM9A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 4.1 nTPM
Expression across tissuesHPA
Tissue
- testis: 4.1 nTPM
- retina: 0.8 nTPM
- liver: 0.3 nTPM
- heart muscle: 0.2 nTPM
- adrenal gland: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
Single-cell type
- early primary spermatocytes: 71 nCPM
- differentiating spermatogonia: 31 nCPM
- undifferentiated spermatogonia: 12 nCPM
- late spermatids: 1 nCPM
- late primary spermatocytes: 0.6 nCPM
- lymphatic endothelial cells: 0.3 nCPM
Immune cell
- eosinophil: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 2.6 nTPM
- pons: 2.3 nTPM
- midbrain: 2.2 nTPM
- amygdala: 2.1 nTPM
- cerebellum: 2 nTPM
- medulla oblongata: 1.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.75
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FAM9A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM9A as an antibody target. Whether an autoantibody or antibody against FAM9A could matter depends on whether native FAM9A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM9A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM9A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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