Seroatlas · Human Serome Atlas

FBXL17

F-box/LRR-repeat protein 17

Also known as: DKFZP434C1715, Fbl17, Fbx13, FBXO13, FXL17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UF56
Gene: FBXL17
Ensembl: ENSG00000145743
Chromosome: 5
Canonical length: 701 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

701 residues, UniProt reviewed canonical sequence.

>Q9UF56|FBXL17
     1  MGHLLSKEPR NRPSQKRPRC CSWCRRRRPL LRLPRRTPAK VPPQPAAPRS RDCFFRGPCM
    61  LCFIVHSPGA PAPAGPEEEP PLSPPPRDGA YAAASSSQHL ARRYAALAAE DCAAAARRFL
   121  LSSAAAAAAA AASASSPASC CKELGLAAAA AWEQQGRSLF LASLGPVRFL GPPAAVQLFR
   181  GPTPSPAELP TPPEMVCKRK GAGVPACTPC KQPRCGGGGC GGGGGGGGGG GPAGGGASPP
   241  RPPDAGCCQA PEQPPQPLCP PPSSPTSEGA PTEAGGDAVR AGGTAPLSAQ QQHECGDADC
   301  RESPENPCDC HREPPPETPD INQLPPSILL KIFSNLSLDE RCLSASLVCK YWRDLCLDFQ
   361  FWKQLDLSSR QQVTDELLEK IASRSQNIIE INISDCRSMS DNGVCVLAFK CPGLLRYTAY
   421  RCKQLSDTSI IAVASHCPLL QKVHVGNQDK LTDEGLKQLG SKCRELKDIH FGQCYKISDE
   481  GMIVIAKGCL KLQRIYMQEN KLVTDQSVKA FAEHCPELQY VGFMGCSVTS KGVIHLTKLR
   541  NLSSLDLRHI TELDNETVME IVKRCKNLSS LNLCLNWIIN DRCVEVIAKE GQNLKELYLV
   601  SCKITDYALI AIGRYSMTIE TVDVGWCKEI TDQGATLIAQ SSKSLRYLGL MRCDKVNEVT
   661  VEQLVQQYPH ITFSTVLQDC KRTLERAYQM GWTPNMSAAS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 41 nTPM
tongue: 30 nTPM
heart muscle: 19 nTPM
parathyroid gland: 19 nTPM
retina: 18 nTPM
thyroid gland: 18 nTPM

Single-cell type

myonuclei: 1,151 nCPM
cone photoreceptor cells: 789 nCPM
rod photoreceptor cells: 718 nCPM
cardiomyocytes: 716 nCPM
distal convoluted tubule cells: 715 nCPM
brain inhibitory neurons: 685 nCPM

Immune cell

eosinophil: 0.6 nTPM
gdT-cell: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM

Brain region

cerebral cortex: 38 nTPM
basal ganglia: 37 nTPM
hypothalamus: 36 nTPM
midbrain: 35 nTPM
amygdala: 34 nTPM
thalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 2.17
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL17 as an antibody target. Whether an autoantibody or antibody against FBXL17 could matter depends on whether native FBXL17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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