Seroatlas · Human Serome Atlas

PRMT8

Protein arginine N-methyltransferase 8

Also known as: ANM8_HUMAN, HRMT1L3, HRMT1L4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NR22
Gene
PRMT8
Ensembl
ENSG00000111218
Chromosome
12
Canonical length
394 aa
Protein class
Enzymes, Predicted intracellular proteins
Quaternary structure
Homooctamer

OverviewNCBI Gene

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q9NR22|PRMT8
     1  MGMKHSSRCL LLRRKMAENA AESTEVNSPP SQPPQPVVPA KPVQCVHHVS TQPSCPGRGK
    61  MSKLLNPEEM TSRDYYFDSY AHFGIHEEML KDEVRTLTYR NSMYHNKHVF KDKVVLDVGS
   121  GTGILSMFAA KAGAKKVFGI ECSSISDYSE KIIKANHLDN IITIFKGKVE EVELPVEKVD
   181  IIISEWMGYC LFYESMLNTV IFARDKWLKP GGLMFPDRAA LYVVAIEDRQ YKDFKIHWWE
   241  NVYGFDMTCI RDVAMKEPLV DIVDPKQVVT NACLIKEVDI YTVKTEELSF TSAFCLQIQR
   301  NDYVHALVTY FNIEFTKCHK KMGFSTAPDA PYTHWKQTVF YLEDYLTVRR GEEIYGTISM
   361  KPNAKNVRDL DFTVDLDFKG QLCETSVSND YKMR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRMT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 24 nTPM
  • cerebral cortex: 18 nTPM
  • cerebellum: 12 nTPM
  • amygdala: 5.1 nTPM
  • hippocampal formation: 4.7 nTPM
  • midbrain: 4 nTPM

Single-cell type

  • respiratory ciliated cells: 183 nCPM
  • brain inhibitory neurons: 102 nCPM
  • retinal amacrine cells: 73 nCPM
  • retinal bipolar cells: 67 nCPM
  • transitional alveolar cells: 63 nCPM
  • brain excitatory neurons: 43 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 18 nTPM
  • cerebral cortex: 16 nTPM
  • thalamus: 9.7 nTPM
  • white matter: 9.6 nTPM
  • cerebellum: 9.5 nTPM
  • midbrain: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
3.46
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRMT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRMT8 as an antibody target. Whether an autoantibody or antibody against PRMT8 could matter depends on whether native PRMT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRMT8 is annotated at the cell surface, where native PRMT8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRMT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRMT8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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