Seroatlas · Human Serome Atlas

BTG1

Protein BTG1

Also known as: APRO2, BTG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62324
Gene: BTG1
Ensembl: ENSG00000133639
Chromosome: 12
Canonical length: 171 aa
Protein class: Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

171 residues, UniProt reviewed canonical sequence.

>P62324|BTG1
     1  MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK
    61  PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS
   121  ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 89 nTPM
lymph node: 22 nTPM
spleen: 22 nTPM
skin: 21 nTPM
appendix: 19 nTPM
thymus: 19 nTPM

Single-cell type

t-cells: 2,533 nCPM
b-cells: 2,094 nCPM
neutrophils: 2,082 nCPM
innate lymphoid cells: 1,945 nCPM
basal keratinocytes: 1,806 nCPM
nk-cells: 1,736 nCPM

Immune cell

eosinophil: 152 nTPM
naive CD4 T-cell: 134 nTPM
naive B-cell: 106 nTPM
memory B-cell: 93 nTPM
neutrophil: 76 nTPM
NK-cell: 69 nTPM

Brain region

cerebellum: 74 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 15 nTPM
medulla oblongata: 14 nTPM
pons: 13 nTPM
spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.54
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BTG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTG1 as an antibody target. Whether an autoantibody or antibody against BTG1 could matter depends on whether native BTG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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